Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines

Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines Publisher Pubmed

Akrami H¹ ; Safavi M² ; Mirjalili BF¹ ; Dehghani Ashkezari M³ ; Dadfar F³ ; Mohaghegh N¹ ; Emami S⁴ ; Salehi F⁵ ; Nadri H⁶ ; Ardestani SK⁵ ; Firoozpour L⁷ ; Khoobi M^{8, 9} ; Foroumadi A^{7, 8}

Show Affiliations

1. Department of Chemistry, College of Science, Yazd University, Yazd, 8915813149, Iran
2. Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
3. Department of Biology, Ashkezar Branch, Islamic Azad University, Ashkezar, Iran
4. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
5. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
6. Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
8. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Medicinal Chemistry Published:2017

Abstract

A series of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines 6a-t were synthesized as new potential antiproliferative agents. The in vitro antiproliferative activity evaluation of title compounds using MTT assay revealed that most compounds showed significant activity against tested cancer cell lines (A549, MOLT-4, and HeLa). The 2-fluoro-aniline derivatives 6e and 6l were the most active compounds against A549 and MOLT-4 cells, respectively. The benzylamine analog 6h showed superior activity against HeLa cells. However, compound 6l with IC50values of 5.2–6.9 μM had the best profile of activity against all tested cell lines. The morphological and flow cytometric analyses showed that compound 6l can induce apoptosis in the MOLT-4 cells. © 2016 Elsevier Masson SAS

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Style	Citing Format
MLA	Akrami H, et al.. "Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines." European Journal of Medicinal Chemistry, vol. 127, no. , 2017, pp. 128-136.
APA	Akrami H, Safavi M, Mirjalili BF, Dehghani Ashkezari M, Dadfar F, Mohaghegh N, Emami S, Salehi F, Nadri H, Ardestani SK, Firoozpour L, Khoobi M, Foroumadi A (2017). Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines. European Journal of Medicinal Chemistry, 127(), 128-136.
Chicago	Akrami H, Safavi M, Mirjalili BF, Dehghani Ashkezari M, Dadfar F, Mohaghegh N, Emami S, et al.. "Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines." European Journal of Medicinal Chemistry 127, no. (2017): 128-136.
Harvard	Akrami H et al. (2017) 'Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines', European Journal of Medicinal Chemistry, 127(), pp. 128-136.
Vancouver	Akrami H, Safavi M, Mirjalili BF, Dehghani Ashkezari M, Dadfar F, Mohaghegh N, et al.. Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines. European Journal of Medicinal Chemistry. 2017;127():128-136.
BibTex	@article{ author = {Akrami H and Safavi M and Mirjalili BF and Dehghani Ashkezari M and Dadfar F and Mohaghegh N and Emami S and Salehi F and Nadri H and Ardestani SK and Firoozpour L and Khoobi M and Foroumadi A}, title = {Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines}, journal = {European Journal of Medicinal Chemistry}, volume = {127}, number = {}, pages = {128-136}, year = {2017} }
RIS	TY - JOUR AU - Akrami H AU - Safavi M AU - Mirjalili BF AU - Dehghani Ashkezari M AU - Dadfar F AU - Mohaghegh N AU - Emami S AU - Salehi F AU - Nadri H AU - Ardestani SK AU - Firoozpour L AU - Khoobi M AU - Foroumadi A TI - Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines JO - European Journal of Medicinal Chemistry VL - 127 IS - SP - 128 EP - 136 PY - 2017 ER -

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