Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents

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Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents Publisher

Mohammadikhanaposhtani M¹ ; Fahimi K² ; Karimpourrazkenari E³ ; Safavi M⁴ ; Mahdavi M⁵ ; Saeedi M^{3, 6} ; Akbarzadeh T^{2, 3}

Source: Letters in Drug Design and Discovery Published:2019

Abstract

Background: This work reports design, synthesis, and in vitro cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids against three breast cancer cell lines MCF-7, MDA-MB-231, and T-47D. Methods: Synthetic procedure for the preparation of desired compounds was started from the reaction of coumarins or with propargyl bromide to give O-propargylated coumarins or 5. Then, click reaction between the later compounds and 3-aryl-5-(chloromethyl)-1,2,4-oxadiazoles afforded the desired products in good yields. Results: Among the synthesized compounds, 4-((1-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)-2H-chromen-2-one (9a) showed the best cytotoxicity against breast cancer cell lines. Conclusion: Compound 9a depicted the most activity toward MDA-MB-231 and T-47D cells while compounds 8a and 8c were the most potent compounds against MCF-7. ©2019 Bentham Science Publishers.

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Style	Citing Format
MLA	Mohammadikhanaposhtani M, et al.. "Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents." Letters in Drug Design and Discovery, vol. 16, no. 7, 2019, pp. 818-824.
APA	Mohammadikhanaposhtani M, Fahimi K, Karimpourrazkenari E, Safavi M, Mahdavi M, Saeedi M, Akbarzadeh T (2019). Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents. Letters in Drug Design and Discovery, 16(7), 818-824.
Chicago	Mohammadikhanaposhtani M, Fahimi K, Karimpourrazkenari E, Safavi M, Mahdavi M, Saeedi M, Akbarzadeh T. "Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents." Letters in Drug Design and Discovery 16, no. 7 (2019): 818-824.
Harvard	Mohammadikhanaposhtani M et al. (2019) 'Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents', Letters in Drug Design and Discovery, 16(7), pp. 818-824.
Vancouver	Mohammadikhanaposhtani M, Fahimi K, Karimpourrazkenari E, Safavi M, Mahdavi M, Saeedi M, et al.. Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents. Letters in Drug Design and Discovery. 2019;16(7):818-824.
BibTex	@article{ author = {Mohammadikhanaposhtani M and Fahimi K and Karimpourrazkenari E and Safavi M and Mahdavi M and Saeedi M and Akbarzadeh T}, title = {Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents}, journal = {Letters in Drug Design and Discovery}, volume = {16}, number = {7}, pages = {818-824}, year = {2019} }
RIS	TY - JOUR AU - Mohammadikhanaposhtani M AU - Fahimi K AU - Karimpourrazkenari E AU - Safavi M AU - Mahdavi M AU - Saeedi M AU - Akbarzadeh T TI - Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents JO - Letters in Drug Design and Discovery VL - 16 IS - 7 SP - 818 EP - 824 PY - 2019 ER -

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