Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent

Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent Publisher

Montazerabadi AR^{1, 2} ; Oghabian MA^{1, 2} ; Irajirad R² ; Muhammadnejad S² ; Ahmadvand D³ ; Hamid Delavari H⁴ ; Mahdavi SR⁵

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1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Biomolecular Image Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Iran
3. School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
4. Department of Materials Science and Engineering, Tarbiat Modares University, P.O. Box: 14115-143, Tehran, Iran
5. Department of Medical Physics, Faculty of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: Nano Published:2015

Abstract

Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methyl-polyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The synthesized mPEG-core@shells are characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis and X-ray diffraction (XRD). In addition, the transverse relaxivity of the mPEG-core@shells is measured using a 3 T MRI scanner. The cytotoxicity of the mPEG-core@shells is tested in the LNCaP cell line using an 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the mPEG-core@shell particles are semispherical with hydrodynamic size of ∼65 nm and a transverse relaxivity of 162.3 mM-1 S-1. The mPEG-core@shell particles demonstrate good stability in biological media without any significant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging shows that mPEG-core@shells are a potential contrast agent for use in early-stage detection. © 2015 World Scientific Publishing Company.

Style	Citing Format
MLA	Montazerabadi AR, et al.. "Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent." Nano, vol. 10, no. 4, 2015, pp. -.
APA	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, Mahdavi SR (2015). Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent. Nano, 10(4), -.
Chicago	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, Mahdavi SR. "Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent." Nano 10, no. 4 (2015): -.
Harvard	Montazerabadi AR et al. (2015) 'Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent', Nano, 10(4), pp. -.
Vancouver	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, et al.. Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent. Nano. 2015;10(4):-.
BibTex	@article{ author = {Montazerabadi AR and Oghabian MA and Irajirad R and Muhammadnejad S and Ahmadvand D and Hamid Delavari H and Mahdavi SR}, title = {Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent}, journal = {Nano}, volume = {10}, number = {4}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Montazerabadi AR AU - Oghabian MA AU - Irajirad R AU - Muhammadnejad S AU - Ahmadvand D AU - Hamid Delavari H AU - Mahdavi SR TI - Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent JO - Nano VL - 10 IS - 4 SP - EP - PY - 2015 ER -

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