Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent

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Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent Publisher

Montazerabadi AR^{1, 2} ; Oghabian MA^{1, 2} ; Irajirad R² ; Muhammadnejad S² ; Ahmadvand D³ ; Hamid Delavari H⁴ ; Mahdavi SR⁵

Source: Nano Published:2015

Abstract

Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methyl-polyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The synthesized mPEG-core@shells are characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis and X-ray diffraction (XRD). In addition, the transverse relaxivity of the mPEG-core@shells is measured using a 3 T MRI scanner. The cytotoxicity of the mPEG-core@shells is tested in the LNCaP cell line using an 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the mPEG-core@shell particles are semispherical with hydrodynamic size of ∼65 nm and a transverse relaxivity of 162.3 mM-1 S-1. The mPEG-core@shell particles demonstrate good stability in biological media without any significant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging shows that mPEG-core@shells are a potential contrast agent for use in early-stage detection. © 2015 World Scientific Publishing Company.

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Style	Citing Format
MLA	Montazerabadi AR, et al.. "Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent." Nano, vol. 10, no. 4, 2015, pp. -.
APA	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, Mahdavi SR (2015). Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent. Nano, 10(4), -.
Chicago	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, Mahdavi SR. "Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent." Nano 10, no. 4 (2015): -.
Harvard	Montazerabadi AR et al. (2015) 'Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent', Nano, 10(4), pp. -.
Vancouver	Montazerabadi AR, Oghabian MA, Irajirad R, Muhammadnejad S, Ahmadvand D, Hamid Delavari H, et al.. Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent. Nano. 2015;10(4):-.
BibTex	@article{ author = {Montazerabadi AR and Oghabian MA and Irajirad R and Muhammadnejad S and Ahmadvand D and Hamid Delavari H and Mahdavi SR}, title = {Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent}, journal = {Nano}, volume = {10}, number = {4}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Montazerabadi AR AU - Oghabian MA AU - Irajirad R AU - Muhammadnejad S AU - Ahmadvand D AU - Hamid Delavari H AU - Mahdavi SR TI - Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent JO - Nano VL - 10 IS - 4 SP - EP - PY - 2015 ER -

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