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Serum Dkk1 Is Correlated With Γ Peak of Serum Electrophoresis in Multiple Myeloma: A Multicenter Biomarker Study Publisher Pubmed



Hashemi ZS1 ; Khalili S2, 3 ; Malaei F2 ; Mardsoltani M4 ; Jafarisani M5 ; Lotfi J6 ; Deemeh MR6 ; Zakeri A3 ; Rasaee MJ2
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran
  5. 5. Clinical Biochemistry, Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  6. 6. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Biomarkers in Medicine Published:2019


Abstract

Aim: DKK1 is reported to be produced at high levels by myeloma cells. Therefore, the applicability of DKK1 as a tumor marker for multiple myeloma (MM) diagnosis was examined. Methods: Serum samples were collected and analyzed by DKK1 concentration kit and capillary zone electrophoresis. Then, the obtained results were statically analyzed. Results: It has been determined that the 10 ng/ml of DKK1 is the optimal level for MM diagnosis. Moreover, there was an ascending linear correlation between the DKK1 concentration and γpeak. Discussion: The observed correlation could be rooted in the positive feedback loop between MM cells and the mesenchymal stem cells. In view of these results, DKK1 could be deemed as diagnostic marker for MM. © 2019 Future Medicine Ltd.
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