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Multiple Myeloma Publisher



Biglari M1 ; Shiraji ST1
Authors
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Authors Affiliations
  1. 1. Research Institute for Oncology, Hematology and Cell Therapy, Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Comprehensive Hematology and Stem Cell Research: Volume 1-5 Published:2024


Abstract

Multiple myeloma is exemplified by the clonal proliferation of bone marrow plasma cells, with concomitant symptoms of anemia, renal impairment, bone lesions, and immunodeficiency. Emerging targeted therapies including immunomodulatory agents, proteasome inhibitors, and monoclonal antibodies have significantly improved disease prognosis. Treatment involves a personalized approach, encompassing induction treatment, stem cell transplantation, and maintenance regimens. Recent advancements like CAR-T cell treatment, in which redesigned patient's T cells are infused to eliminate certain myeloma antigens, show promise, especially in relapsed or refractory cases. Ongoing research continues to refine therapeutic strategies, aiming for deeper responses and prolonged remissions, ultimately enhancing patients' survival and quality of life. © 2024 Elsevier Inc. All rights are reserved.
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