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Mesenchymal Stromal Cells in Bone Marrow Niche of Patients With Multiple Myeloma: A Double-Edged Sword Publisher



Kamrani S1 ; Naseramini R1 ; Khani P2 ; Razavi ZS3 ; Afkhami H4, 5, 6 ; Atashzar MR7 ; Nasri F8 ; Alavimanesh S9, 10 ; Saeidi F11 ; Ronaghi H1
Authors
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Authors Affiliations
  1. 1. Department of Orthopedic, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
  5. 5. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
  6. 6. Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
  7. 7. Department of Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  8. 8. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
  10. 10. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  11. 11. Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Cancer Cell International Published:2025


Abstract

Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within the bone marrow (BM). While multiple myeloma impacts the bone, it is not classified as a primary bone cancer. The bone marrow microenvironment significantly influences the progression of myeloma and its treatment response. Mesenchymal stromal cells (MSCs) in this environment engage with myeloma cells and other bone marrow components via direct contact and the secretion of soluble factors. This review examines the established roles of MSCs in multiple facets of MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence on reprogramming, chemotherapy resistance, and senescence. This review investigates the role of MSCs in the development and progression of MM. © The Author(s) 2025.
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