Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Diffusion-Weighted Imaging (Dwi) in Diagnosis, Staging, and Treatment Response Assessment of Multiple Myeloma: A Systematic Review and Meta-Analysis Publisher Pubmed



Torkian P1 ; Mansoori B2 ; Hillengass J3 ; Azadbakht J4 ; Rashedi S5 ; Lee SS6 ; Amini B7 ; Bonaffini PA8, 9 ; Chalian M10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN, United States
  2. 2. Department of Radiology, Division Abdominal Imaging, University of Washington, Seattle, 98105, WA, United States
  3. 3. Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States
  4. 4. Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Oncology, University of Washington, Seattle, 98105, WA, United States
  7. 7. Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
  8. 8. Department of Radiology, Papa Giovanni XXIII Hospital, Bergamo, Italy
  9. 9. University Milano Bicocca, Milan, Italy
  10. 10. Department of Radiology, Division Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, 98105, WA, United States

Source: Skeletal Radiology Published:2023


Abstract

Objective: To evaluate the role of diffusion-weighted imaging (DWI) in the initial diagnosis, staging, and assessment of treatment response in patients with multiple myeloma (MM). Materials and methods: A systematic literature review was conducted in PubMed, the Cochrane Library, EMBASE, Scopus, and Web of Science databases. The primary endpoints were defined as the diagnostic performance of DWI for disease detection, staging of MM, and assessing response to treatment in these patients. Results: Of 5881 initially reviewed publications, 33 were included in the final qualitative and quantitative meta-analysis. The diagnostic performance of DWI in the detection of patients with MM revealed pooled sensitivity and specificity of 86% (95% CI: 84–89) and 63% (95% CI: 56–70), respectively, with a diagnostic odds ratio (OR) of 14.98 (95% CI: 4.24–52.91). The pooled risk difference of 0.19 (95% CI: − 0.04–0.42) was reported in favor of upstaging with DWI compared to conventional MRI (P value = 0.1). Treatment response evaluation and ADCmean value changes across different studies showed sensitivity and specificity of approximately 78% (95% CI: 72–83) and 73% (95% CI: 61–83), respectively, with a diagnostic OR of 7.21 in distinguishing responders from non-responders. Conclusions: DWI is not only a promising tool for the diagnosis of MM, but it is also useful in the initial staging and re-staging of the disease and treatment response assessment. This can aid clinicians with earlier initiation or change in treatment strategy, which could have prognostic significance for patients. © 2022, The Author(s), under exclusive licence to International Skeletal Society (ISS).
Related Docs
1. Diffusion Mri for Assessment of Bone Quality; a Review of Findings in Healthy Aging and Osteoporosis, Journal of Magnetic Resonance Imaging (2020)
2. Circrnas in Diagnosis, Prognosis, and Clinicopathological Features of Multiple Myeloma; a Systematic Review and Meta-Analysis, Cancer Cell International (2023)
Experts (# of related papers)
Abbasali Keshtkar (1)
Hamidreza Saligheh Rad (1)