Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Malignancy in Common Variable Immunodeficiency: A Systematic Review and Meta-Analysis Publisher Pubmed



Kiaee F1, 2 ; Azizi G3 ; Rafiemanesh H4 ; Zainaldain H2 ; Sadaat Rizvi F2 ; Alizadeh M5, 6 ; Jamee M6 ; Mohammadi S2 ; Habibi S2 ; Sharifi L7 ; Jadidiniaragh F8, 9 ; Haghi S10 ; Yazdani R2 ; Abolhassani H2, 11 Show All Authors
Authors
  1. Kiaee F1, 2
  2. Azizi G3
  3. Rafiemanesh H4
  4. Zainaldain H2
  5. Sadaat Rizvi F2
  6. Alizadeh M5, 6
  7. Jamee M6
  8. Mohammadi S2
  9. Habibi S2
  10. Sharifi L7
  11. Jadidiniaragh F8, 9
  12. Haghi S10
  13. Yazdani R2
  14. Abolhassani H2, 11
  15. Aghamohammadi A2
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Student Research Committee, Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Evidence- Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Department of Hematology & Oncology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  11. 11. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

Source: Expert Review of Clinical Immunology Published:2019


Abstract

Background: Common variable immunodeficiency (CVID) is the most common clinically significant primary immunodeficiency (PID) disorder characterized by variable clinical manifestations including recurrent infections, autoimmune disorders, enteropathy, lymphoproliferative disorders, and malignancy. The aim of this study is to estimate the overall prevalence of malignancy in patients with CVID. Methods: PubMed, Web of Science and Scopus were searched systemically to find eligible studies from the earliest available date to March 2019 with standard keywords. Pooled estimates of the malignancy prevalence and the corresponding 95% confidence intervals (CI) were calculated using random effects models. Results: Forty-eight studies with a total of 8123 CVID patients met the inclusion criteria and were finally included in the meta-analysis. Overall prevalence of malignancy was 8.6% (95% CI: 7.1–10.0; I2 = 79.2%). The prevalence of lymphoma, gastric cancer, and breast cancer in CVID patients were 4.1% (95% CI: 3.3–4.9; I2 = 62.6%), 1.5% (95% CI: 0.78–2.2; I2 = 68.9%), and 1.3% (95% CI: 0.64–1.9; I2 = 54.9%), respectively. Moreover, autoimmunity and malabsorption were more frequent in patients with malignancy than those without malignancy. Conclusion: The prevalence of malignancy has increased in CVID patients due to recent improvement in survival rate and the lymphoma is the most common type. This research highlighted the significance of malignancy screening and management in CVID patients. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-Analysis, Journal of Clinical Immunology (2025)
2. Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?, Allergologia et Immunopathologia (2017)
3. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management, Journal of Investigational Allergology and Clinical Immunology (2020)
4. Autoimmune Disorders Associated With Common Variable Immunodeficiency: Prediction, Diagnosis, and Treatment, Expert Review of Clinical Immunology (2022)
5. Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity, Frontiers in Immunology (2021)
6. Bronchiectasis in Common Variable Immunodeficiency: A Systematic Review and Meta-Analysis, Pediatric Pulmonology (2020)
7. Abnormality of Regulatory T Cells in Common Variable Immunodeficiency, Cellular Immunology (2017)
8. Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management, Expert Review of Clinical Immunology (2017)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (41)
Laleh Sharifi (6)
Other Related Docs
9. Inborn Errors of Immunity and Cancers, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
10. A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2017)
11. Autoimmunity in Common Variable Immunodeficiency: A Systematic Review and Meta-Analysis, Expert Review of Clinical Immunology (2020)
12. Transcriptional Regulation of B Cell Class-Switch Recombination: The Role in Development of Noninfectious Complications, Expert Review of Clinical Immunology (2022)
13. Phenotyping and Follow up of Forty-Seven Iranian Patients With Common Variable Immunodeficiency, Allergologia et Immunopathologia (2016)
14. T-Cell Abnormalities in Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2016)
15. Comparison of Clinical and Immunological Features and Mortality in Common Variable Immunodeficiency and Agammaglobulinemia Patients, Immunology Letters (2019)
16. The Clinical and Immunological Features of Patients With Primary Antibody Deficiencies, Endocrine# Metabolic and Immune Disorders - Drug Targets (2018)
17. Circulating Helper T-Cell Subsets and Regulatory T Cells in Patients With Common Variable Immunodeficiency Without Known Monogenic Disease, Journal of Investigational Allergology and Clinical Immunology (2018)
18. Autoimmunity and Its Association With Regulatory T Cells and B Cell Subsets in Patients With Common Variable Immunodeficiency, Allergologia et Immunopathologia (2018)
19. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
20. The Evaluation of Neutropenia in Common Variable Immune Deficiency Patients, Expert Review of Clinical Immunology (2019)
21. The Profile of Il-4, Il-5, Il-10 and Gata3 in Patients With Lrba Deficiency and Cvid With No Known Monogenic Disease: Association With Disease Severity, Allergologia et Immunopathologia (2019)
22. Comprehensive Assessment of Respiratory Complications in Patients With Common Variable Immunodeficiency, Annals of Allergy# Asthma and Immunology (2020)
23. Lymphocytes Subsets in Correlation With Clinical Profile in Cvid Patients Without Monogenic Defects, Expert Review of Clinical Immunology (2021)
24. Important Factors Influencing Severity of Common Variable Immunodeficiency, Archives of Iranian Medicine (2016)
25. Rheumatologic Complications in a Cohort of 227 Patients With Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2018)
26. Primary Immunodeficiencies and Cancers, Cancer Immunology: A Translational Medicine Context (2015)
27. Common Presentations and Diagnostic Approaches, Stiehm's Immune Deficiencies: Inborn Errors of Immunity (2020)
28. Infectious Complications Reporting in Common Variable Immunodeficiency: A Systematic Review and Meta-Analysis, Oman Medical Journal (2020)
29. Clinical and Immunologic Characteristics of Non-Hematologic Cancers in Patients With Inborn Errors of Immunity, Cancers (2023)
30. Important Differences in the Diagnostic Spectrum of Primary Immunodeficiency in Adults Versus Children, Expert Review of Clinical Immunology (2015)
31. Application of Flow Cytometry in Predominantly Antibody Deficiencies, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
32. Role of Apoptosis in the Pathogenesis of Common Variable Immunodeficiency (Cvid), Endocrine# Metabolic and Immune Disorders - Drug Targets (2017)
33. Pulmonary Manifestations of Predominantly Antibody Deficiencies, Pulmonary Manifestations of Primary Immunodeficiency Diseases (2018)
34. Long-Term Follow-Up of Ninety Eight Iranian Patients With Primary Immune Deficiency in a Single Tertiary Centre, Allergologia et Immunopathologia (2016)
35. Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders, Journal of Investigational Allergology and Clinical Immunology (2017)
36. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)
37. Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies, Pediatric Allergy and Immunology (2021)
38. G2-Lymphocyte Chromosomal Radiosensitivity in Patients With Lps Responsive Beige-Like Anchor Protein (Lrba) Deficiency, International Journal of Radiation Biology (2019)
39. Increased Expression of B Lymphocyte Induced Maturation Protein 1 (Blimp1) in Patients With Common Variable Immunodeficiency (Cvid), Iranian Journal of Allergy# Asthma and Immunology (2020)
40. Evaluation of the Tlr Negative Regulatory Network in Cvid Patients, Genes and Immunity (2019)
41. Approach to the Management of Autoimmunity in Primary Immunodeficiency, Scandinavian Journal of Immunology (2017)
42. Comprehensive Assessment of Skin Disorders in Patients With Common Variable Immunodeficiency (Cvid), Journal of Clinical Immunology (2022)
43. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
44. Activated Phosphoinositide 3-Kinase Δ Syndrome: Update From the Esid Registry and Comparison With Other Autoimmune-Lymphoproliferative Inborn Errors of Immunity, Journal of Allergy and Clinical Immunology (2023)
45. Diversity of Malignancies in Patients With Different Types of Inborn Errors of Immunity, Allergy# Asthma and Clinical Immunology (2022)
46. Increased Irf4 Expression in Isolated B Cells From Common Variable Immunodeficiency (Cvid) Patients, Allergologia et Immunopathologia (2019)
47. Genomic Characterization of Lymphomas in Patients With Inborn Errors of Immunity, Blood Advances (2022)
48. Evaluation of Mir-210 Expression in Common Variable Immunodeficiency: Patients With Unsolved Genetic Defect, Allergologia et Immunopathologia (2021)
49. Primary Immunodeficiency Diseases in Iran: Past, Present and Future, Archives of Iranian Medicine (2021)
50. Mannose-Binding Lectin Protein Deficiency Among Patients With Primary Immunodeficiency Disease Receiving Ivig Therapy, Endocrine# Metabolic and Immune Disorders - Drug Targets (2018)