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Abnormality of Regulatory T Cells in Common Variable Immunodeficiency Publisher Pubmed



Azizi G1, 2, 3 ; Hafezi N4 ; Mohammadi H5 ; Yazdai R1, 6 ; Alinia T1 ; Tavakol M7 ; Aghamohammadi A1, 3 ; Mirshafiey A8
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular Immunology Published:2017


Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies (PAD) which is defined by recurrent infections, hypogammaglobulinemia and defects in B-cell differentiation into plasma cells and memory B cells. T cell abnormalities have also been described in CVID patients. Several studies reported that Treg frequencies and their functional characteristics are disturbed and might account for the aberrant immune responses observed in CVID patients. The aim of this review is to describe phenotypic and functional characteristics of Treg cells, and to review the literature with respect to the reported Treg defects and its association with the clinical manifestation in CVID. © 2016
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