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The Effects of a Melissa Officinalis L. Based Product on Metabolic Parameters in Patients With Type 2 Diabetes Mellitus: A Randomized Double-Blinded Controlled Clinical Trial Publisher Pubmed



Nayebi N1 ; Esteghamati A2 ; Meysamie A3 ; Khalili N4 ; Kamalinejad M5 ; Emtiazy M1, 6 ; Hashempur MH7
Authors
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Authors Affiliations
  1. 1. School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, 8951737915, Iran
  2. 2. Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community and Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Baqiatallah University of Medical Sciences, Health Research Center, Life Style Institute, Tehran, Iran
  5. 5. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
  6. 6. Research Center of The Persian Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

Source: Journal of Complementary and Integrative Medicine Published:2020


Abstract

Background: Diabetic patients are at increased risk for coronary artery disease. Since phytotherapy has been greatly common, finding safe and effective treatments is of importance. This study aimed to evaluate the effects of a Melissa officinalis L. based product (MO) in patients with type 2 diabetes. Methods: A randomized double-blinded controlled study was conducted with 37 dyslipidemic diabetic patients, assigned to either MO or placebo (P) groups receiving two 500 mg capsules daily for 3 months. Finally, 32 cases completed the study and were included in the analysis; MO (n=16) and P (n=16). Results: Safe and significant effects in terms of decreasing the serum level of triglyceride (TG) in all patients after 2 months (p-value=0.02) and in patients with higher baseline serum levels of TG (TG≥200 mg/dl) after 3 months (p-value=0.04) were shown in the MO group. However, no metabolic significant changes were seen compared to the control group. Significant decrease in both systolic and diastolic blood pressure from baseline values were also found in patients with higher systolic blood pressure (SBP≥130 mmHg) (p-value=0.02) and those with higher diastolic blood pressure (DBP≥85 mmHg) (p-value=0.02) in the MO group. Conclusion: This study showed that MO might be safe and beneficial in decreasing the serum TG level in dyslipidemic diabetic patients. Although, larger long-term studies are required. © 2019 Walter de Gruyter GmbH, Berlin/Boston.
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