Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dietary Intake of Fatty Acids and Risk of Pancreatic Cancer: Golestan Cohort Study Publisher Pubmed



Ghamarzad Shishavan N1 ; Masoudi S1 ; Mohamadkhani A2 ; Sepanlou SG1 ; Sharafkhah M1 ; Poustchi H2 ; Mohamadnejad M1 ; Hekmatdoost A3 ; Pourshams A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Departments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Nutrition Journal Published:2021


Abstract

Background: As pancreatic cancer (PC) is a malignancy with poor prognosis, finding strategies for its prevention became a notable priority. Among all the factors influencing the risk of PC, dietary items especially fats are considered as the most modifiable risk factors.This study is designed to assess the associations of dietary intake of fatty acids with the risk of PC incidence. Methods: A total of 50,045 adults between 40 and 75 years old participated in this cohort study in 2004–2008 and were followed up to the present. Intakes of fatty acids was evaluated by validated food-frequency questionnaire (FFQ). Cox proportional hazards regression model was used to estimate hazard ratio (HR) with 95 % confidence interval of differing levels of dietary intakes of fatty acids for incidence of PC. Results: At the end of follow-up period, 76 cases of PC were identified and 46,904 participants without history of cancer, acute kidney disorders, fibrosis and cirrhosis were included in the study. Dietary total saturated fatty acids (SFAS) was associated with PC risk (HR = 1.05 (1.01–1.09), Ptrend=0.01), whereas dietary total monounsaturated fatty acids (MUFAS) was inversely associated with the risk of PC (HR = 0.92 (0.86–0.99), Ptrend=0.04). Dietary total polyunsaturated fatty acids (PUFAS) did show a protective but not significant association with the risk of PC (HR = 0.91(0.84-1.00), Ptrend=0.05). Conclusions: The amount of total fat intake is not a risk factor for PC in our study and focusing on the intake of specific fatty acids becomes more striking. Unsaturated fatty acids including PUFAS and especially MUFAS are considered as protective dietary factors in PC prevention. In contrast, total SFAS is positively associated with the increased risk of PC. However, very long chain and odd-chain saturated fatty acids intake may be protective against PC. © 2021, The Author(s).
Related Docs
View other Related Docs
1. The Association Between Dietary Fat Intake and Pancreatic Cancer Risk: A Large Prospective Study, Govaresh (2017)
2. Major Dietary Protein Sources in Relation to Pancreatic Cancer: A Large Prospective Study, Archives of Iranian Medicine (2016)
3. Higher Intake of Dietary Fiber, But Not Fruits or Vegetables Is Associated With Lower Risk of Pancreatic Cancer: A Large Prospective Study, Govaresh (2017)
4. Circulating Plasma Fatty Acids and Risk of Pancreatic Cancer: Results From the Golestan Cohort Study, Clinical Nutrition (2021)
5. The Association Between Dietary Carbohydrate Intake and Pancreatic Cancer Risk: A Large Prospective Study, Govaresh (2016)
6. Dietary Food Groups Intake and Cooking Methods Associations With Pancreatic Cancer: A Case-Control Study, Indian Journal of Gastroenterology (2015)
7. The Association of Dietary Intake and Plasma Fatty Acid Panel in Pancreatic Cancer Patients: Results From Golestan Cohort Study, Nutrition and Health (2022)
8. Dietary Quality Using Four Dietary Indices and Lung Cancer Risk: The Golestan Cohort Study (Gcs), Cancer Causes and Control (2021)
Experts (# of related papers)
View all Related Experts
Hossein Poustchi (39)
Reza Malekzadeh (35)
Other Related Docs
9. White Rice Intake and Incidence of Type-2 Diabetes: Analysis of Two Prospective Cohort Studies From Iran, BMC Public Health (2017)
10. The Relationship Between Dietary Patterns, Dietary Quality Index, and Dietary Inflammatory Index With the Risk of All Types of Cancer: Golestan Cohort Study, Medical Journal of the Islamic Republic of Iran (2021)
11. Urinary Nitrate and Sodium in a High-Risk Area for Upper Gastrointestinal Cancers: Golestan Cohort Study☆, Environmental Research (2022)
12. Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study, American Journal of Clinical Nutrition (2015)
13. Population Attributable Fraction of Dietary Risk Factors for Cancer Mortality With a Focus on Gastrointestinal Cancers in a Population Based Cohort Study, Scientific Reports (2025)
14. The Interactions Between Dietary Fats Intake and Caveolin 1 Rs 3807992 Polymorphism With Fat Distribution in Overweight and Obese Women: A Cross-Sectional Study, BMC Medical Genomics (2021)
15. Mineral Intake and Cardiovascular Disease, Cancer, and All-Cause Mortality: Findings From the Golestan Cohort Study, Nutrients (2024)
16. Can Nutritional Scores Improve the Who Calibrated Non-Laboratory Risk Prediction Model for Cardiovascular Disease? Golestan Cohort Study, Journal of Diabetes and Metabolic Disorders (2024)
17. Joint Effect of Diabetes and Opiate Use on All-Cause and Cause-Specific Mortality: The Golestan Cohort Study, International Journal of Epidemiology (2021)
18. Sex and Smoking Differences in the Association Between Gastroesophageal Reflux and Risk of Esophageal Squamous Cell Carcinoma in a High-Incidence Area: Golestan Cohort Study, International Journal of Cancer (2023)
19. Adherence to the Dietary Approaches to Stop Hypertension (Dash) Diet and Risk of Total and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Epidemiology (2019)
20. The Protocol of a Population-Based Prospective Cohort Study in Southwest of Iran to Analyze Common Non-Communicable Diseases: Shahrekord Cohort Study, BMC Public Health (2018)
21. Nut Consumption and the Risk of Oesophageal Squamous Cell Carcinoma in the Golestan Cohort Study, British Journal of Cancer (2018)
22. Dietary Protein Sources and All-Cause and Cause-Specific Mortality: The Golestan Cohort Study in Iran, American Journal of Preventive Medicine (2017)
23. Turmeric, Pepper, Cinnamon, and Saffron Consumption and Mortality, Journal of the American Heart Association (2019)
24. Total, Unprocessed, and Processed Red Meat Intake in Relation to the Risk of Pancreatic Cancer: A Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition ESPEN (2025)
25. Comparing the Risk of Cardiovascular Diseases and All-Cause Mortality in Four Lifestyles With a Combination of High/Low Physical Activity and Healthy/Unhealthy Diet: A Prospective Cohort Study, International Journal of Behavioral Nutrition and Physical Activity (2022)
26. Causes of Premature Death and Their Associated Risk Factors in the Golestan Cohort Study, Iran, BMJ Open (2018)
27. Red Meat Consumption and Risk of Nonalcoholic Fatty Liver Disease in a Population With Low Meat Consumption: The Golestan Cohort Study, American Journal of Gastroenterology (2021)
28. Higher Intakes of Fiber, Total Vegetables, and Fruits May Attenuate the Risk of All-Cause and Cause-Specific Mortality: Findings From a Large Prospective Cohort Study, Nutrition Journal (2023)
29. Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study, Archives of Iranian Medicine (2023)
30. Dietary Advanced Glycation End Products and Risk of Overall and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Environmental Research and Public Health (2023)
31. Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study, Environmental Health Perspectives (2020)
32. Meat Consumption and Risk of Esophageal and Gastric Cancer in the Golestan Cohort Study, Iran, International Journal of Cancer (2022)
33. The Application of Six Dietary Scores to a Middle Eastern Population: A Comparative Analysis of Mortality in a Prospective Study, European Journal of Epidemiology (2019)
34. Dietary Acid Load and Mortality From All Causes, Cvd and Cancer: Results From the Golestan Cohort Study, British Journal of Nutrition (2022)
35. Pars Cohort Study of Non-Communicable Diseases in Iran: Protocol and Preliminary Results, International Journal of Public Health (2017)
36. Dietary Amino Acids Intake and All-Cause and Cause-Specific Mortality: Results From the Golestan Cohort Study, Nutrition Journal (2024)
37. Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study, Gastroenterology (2019)
38. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study, American Journal of Epidemiology (2017)
39. Habitual Dietary Intake of Flavonoids and All-Cause and Cause-Specific Mortality: Golestan Cohort Study, Nutrition Journal (2020)
40. Association Between Prediagnostic Risk Factors and Survival After Colorectal Cancer Diagnosis in Golesten Cohort Study, Scientific Reports (2025)
41. The Combined Effects of Healthy Lifestyle Behaviors on All-Cause Mortality: The Golestan Cohort Study, Archives of Iranian Medicine (2016)
42. Diet Quality and Subsequent Incidence of Upper Gastrointestinal Cancers: Results From the Golestan Cohort Study, Archives of Iranian Medicine (2023)
43. Manganese Intake and Risk of Esophageal Cancer in Golestan Cohort Study, Govaresh (2016)