Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer

Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer Publisher

Jahanbanesfahlan R¹ ; Massoumi B² ; Abbasian M² ; Farnudiyanhabibi A^{3, 4} ; Samadian H⁵ ; Rezaei A⁵ ; Derakhshankhah H⁶ ; Jaymand M⁵

Show Affiliations

1. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Chemistry, Payame Noor University, Tehran, Iran
3. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
6. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Polymer-Plastics Technology and Materials Published:2020

Abstract

Novel thermal- and pH-responsive hollow nanocapsules (HNCaps) were fabricated through the grafting of a thiol-end capped PNIPAAm-b-PAA by thiol-ene “click” reaction onto PMMA HNCaps. The lowest critical solution temperature (LCST) of the fabricated HNCaps was obtained as 38–40°C. The fabricated nanosystem was loaded with doxorubicin hydrochloride (Dox), and its drug loading and encapsulation efficiencies were obtained as 62 and 53%, respectively. The in vitro stimuli-responsive drug release behavior of the fabricated nanomedicine was investigated extensively. The anticancer activity of the drug-loaded HNCaps was evaluated using MTT assay against MCF7 cells. The results exhibited excellent potential of nanosystem as a drug delivery system (DDS) for cancer chemotherapy. © 2020 Taylor & Francis.

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Style	Citing Format
MLA	Jahanbanesfahlan R, et al.. "Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer." Polymer-Plastics Technology and Materials, vol. 59, no. 13, 2020, pp. 1492-1504.
APA	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, Derakhshankhah H, Jaymand M (2020). Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer. Polymer-Plastics Technology and Materials, 59(13), 1492-1504.
Chicago	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, Derakhshankhah H, Jaymand M. "Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer." Polymer-Plastics Technology and Materials 59, no. 13 (2020): 1492-1504.
Harvard	Jahanbanesfahlan R et al. (2020) 'Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer', Polymer-Plastics Technology and Materials, 59(13), pp. 1492-1504.
Vancouver	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, et al.. Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer. Polymer-Plastics Technology and Materials. 2020;59(13):1492-1504.
BibTex	@article{ author = {Jahanbanesfahlan R and Massoumi B and Abbasian M and Farnudiyanhabibi A and Samadian H and Rezaei A and Derakhshankhah H and Jaymand M}, title = {Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer}, journal = {Polymer-Plastics Technology and Materials}, volume = {59}, number = {13}, pages = {1492-1504}, year = {2020} }
RIS	TY - JOUR AU - Jahanbanesfahlan R AU - Massoumi B AU - Abbasian M AU - Farnudiyanhabibi A AU - Samadian H AU - Rezaei A AU - Derakhshankhah H AU - Jaymand M TI - Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer JO - Polymer-Plastics Technology and Materials VL - 59 IS - 13 SP - 1492 EP - 1504 PY - 2020 ER -

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