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Parental Morphine Exposure Affects Repetitive Grooming Actions and Marble Burying Behavior in the Offspring: Potential Relevance for Obsessive-Compulsive Like Behavior Publisher Pubmed



Rohbani K1 ; Sabzevari S1 ; Sadatshirazi MS2 ; Nouri Zadehtehrani S2 ; Ashabi G3 ; Khalifeh S4 ; Aleebrahim M5 ; Zarrindast MR2, 4, 6, 7
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Biophysics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Physiology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran

Source: European Journal of Pharmacology Published:2019


Abstract

Family, adoption and twin studies have highlighted the significant role of heritable influences on individual differences in opioid addiction. Meanwhile, obsessive-compulsive disorder (OCD) is a disorder wherein the individual experiences recurring thoughts that cause irrational fears and anxiety. In the present study, adult male and female rats received morphine solution for 21 days and were drug-free for 10 days. Offspring were used in 4 distinct groups; (1) paternal morphine-exposed, (2) maternal morphine-exposed, (3) maternal and paternal morphine-exposed, and (4) drug-naive subjects. We assessed the grooming behavior and marble burying test as an indicator of obsessive-compulsive behavior. To clarify the mechanisms underlying these changes, the mRNA level of BDNF, the phosphorylation level of CREB and the protein level of D2 dopamine receptor (DR) were evaluated in the nucleus accumbens (NAc). The grooming behavior in male offspring with one or two morphine-abstinent parent(s) increased compared with the offspring of drug naive rats. In addition, the offspring of morphine-exposed parents buried more marbles when compared with the offspring of drug-naive parents. Also, the BDNF mRNA was down-regulated in the NAC. However, the levels of phospho-CREB and D2 DR were elevated. Previous studies indicated that exposure to morphine in adulthood enhances the risk of psychiatric disorders in offspring. OCD is one the comorbid disorders with addiction and increases the risk of substance abuse disorder in patients. In this survey, we found that morphine exposure in parents before gestation can encourage obsessive-compulsive behavior in offspring. © 2019 Elsevier B.V.
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