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Adult Rat Morphine Exposure Changes Morphine Preference, Anxiety, and the Brain Expression of Dopamine Receptors in Male Offspring Publisher Pubmed



Vousooghi N1, 2, 3 ; Sadatshirazi MS1, 3 ; Safavi P3 ; Zeraati R3 ; Akbarabadi A3, 4 ; Makki SM5 ; Nazari S3 ; Zarrindast MR3, 6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Cognitive and Behavioral Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Genetics Laboratory, Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
  5. 5. Department of Psychiatry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran
  8. 8. Institute for Cognitive Science Studies, Tehran, Iran

Source: International Journal of Developmental Neuroscience Published:2018


Abstract

Addiction to drugs, including opioids is the result of an interplay between environmental and genetic factors. It has been shown that the progeny of addict people is at higher risk for drug addiction. However, the mechanisms of such trans-generational effects of drugs are not so clear. Here we have evaluated the effects of parental morphine consumption on anxiety, morphine preference, and mRNA expression of dopamine receptors in F1 and F2 male offspring. Morphine was chronically administered to adult male and female Wistar rats followed by 14-day abstinence before mating. Morphine preference and anxiety-like behavior in the offspring were measured by two-bottle-choice paradigm and elevated-plus maze, respectively. Real-time PCR was used to measure the mRNA expression level of dopamine receptors in the striatum, nucleus accumbens, prefrontal cortex, and hippocampus of F1 animals. The results indicated that F1 but not the F2 male progeny of morphine-exposed parents had a greater preference for morphine, and more anxiety-like behavior compared to the offspring of saline-treated parents. In F1 male progeny of morphine-treated parents, D1 and D5 dopamine receptors were significantly increased in the prefrontal cortex and nucleus accumbens. D5 and D2 receptors were decreased in the hippocampus. D4 dopamine receptor was augmented in striatum and hippocampus and decreased in the prefrontal cortex. Adulthood exposure to chronic morphine in male and female rats before conception leads to higher morphine preference and increased anxiety in F1 but not F2 male progeny. Alterations of dopamine receptor expression in the reward system may be one mechanism responsible for observed changes in F1 offspring. © 2018 ISDN
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