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Comparison of Mucin-1 in Human Breast Cancer and Canine Mammary Gland Tumor: A Review Study Publisher



Vafaei R1 ; Samadi M1 ; Hosseinzadeh A1 ; Barzaman K1, 3 ; Esmailinejad MR4 ; Khaki Z1, 2 ; Farahmand L1
Authors
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Authors Affiliations
  1. 1. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, Iran
  2. 2. Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Source: Cancer Cell International Published:2022


Abstract

Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs. © 2022, The Author(s).
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