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A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency Publisher Pubmed



Sharifi L1 ; Tavakolinia N1 ; Kiaee F1 ; Rezaei N1, 3, 4 ; Mohsenzadegan M5 ; Azizi G6, 7 ; Yazdani R1, 8 ; Shariat M9 ; Mirshafiey A1, 10 ; Aghamohammadi A1, 2
Authors
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Authors Affiliations
  1. 1. Research Center for Immunode ciencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom
  5. 5. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Non Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Immunology and Allergy, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2017


Abstract

Background and Objectives: Common variable immunodeficiency (CVID) is the most important primary disorder that is associated with clinical complications including recurrent infections, malignancy and autoimmune diseases. The genetic cause of CVID is mostly unknown and only a few genetic causes are identified. The various options are proposed for determining the etiology of CVID patients, such as T- and B-cell defects, Toll-like receptors (TLRs) impairments, altered cytokine production as well as blemished dendritic cells (DCs). The patients with CVID show a reduction in number and frequency of DCs in blood, an altered expression of cell surface molecules, and defective activation through toll-like receptors (TLRs). Also loss of IFNα has a critical role in B-cell impairments of CVID patients. The aim of this review is to collect under one umbrella, all the recent knowledge about DCs defects of CVID patients. Methods: This review covers basic information about physiology of DCs followed by reports of DCs situation in CVID. Conclusion: According to the results of researches assessing DCs frequency and function in CVID, the roll of DCs in the pathogenesis of CVID cannot be ruled out. The article is expected to encourage the researchers to do comprehensive researches about complex connections between DCs and other immune cells in CVID. © 2017 Bentham Science Publishers.
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