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Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed As Common Variable Immunodeficiency Publisher Pubmed



Yazdani R1, 2 ; Abolhassani H2, 3 ; Rezaei N2, 4, 5 ; Azizi G6 ; Hammarstrom L3 ; Aghamohammadi A2
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Science, 62 Qarib St., Keshavarz Blvd., Tehran, 14194, Iran
  3. 3. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
  4. 4. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  6. 6. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran

Source: International Reviews of Immunology Published:2016


Abstract

Common variable immunodeficiency (CVID) is a primary immunodeficiency disease, associated with defective antibody production and recurrent infections. Several defective signaling-associated molecules related to B-cell receptor, T-cell receptor, toll-like receptor, and other immune cell-associated receptors have been identified so far. In this review, defects of cell signaling associated molecules at three levels of surface cytoplasmic, and nuclear molecules are highlighted in patients who primarily diagnosed as CVID. It could be suggested that impaired cell signaling may be involved in the pathogenesis of CVID. Copyright © 2016 Taylor & Francis Group, LLC.
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