The Role of the Therapeutic Potential of Noncoding Rnas in Fungal Keratitis. a Studies Review Publisher



Nami S^{1, 3} ; Marofi F^{2, 3} ; Hazratian T¹ ; Spotin A¹ ; Gurttapeh BE² ; Torab Z⁴ ; Hassanpour P⁵ Show Affiliations
Source: Reviews and Research in Medical Microbiology Published:2023

Abstract

Fungal keratitis is regarded as the main culprit for the globally prevalent blindness and visual impairment, with contact lenses and traumatic injury being the chief contributors to the disease in developing countries. The incorporation of the function of noncoding RNAs (ncRNAs) into the genomic investigations of fungal keratitis disease can pave the way for the development of novel diagnostic markers and disease-modifying treatments. During the last decade, the expression and function of eukaryotic genomes are proved to be predominantly regulated by ∼20-30 nucleotide RNA molecules. Functioning in both somatic and germline line-ages in a vast array of eukaryotic species, two major categories of these small RNAs- short interfering RNAs (siRNAs) and microRNAs (miRNAs)-modulate endogenous genes and safeguard the genome against invasive nucleic acids. Recent progress has lifted the veil of a stunning diversity in their biogenesis pathways and the regulatory mechanisms at their disposal. Fundamental biology, as well as disease etiology and treatment, can reap the rewards of our precise perception of siRNA and miRNA based regulation. The current review strives to shed light on recent advances made in the realm of pathogenesis, risk factors, and the role of ncRNAs in fungal keratitis. © 2023 Lippincott Williams and Wilkins. All rights reserved.