Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
An Overview on Terbium Sensitized Based-Optical Sensors/Nanosensors for Determination of Pharmaceuticals Publisher



Mohammadian E1 ; Rahimpour E2, 3 ; Alizadehsani M4 ; Foroumadi A1, 5 ; Jouyban A2, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Student’s Scientific Research Center, Department of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Applied Spectroscopy Reviews Published:2022


Abstract

Terbium (Tb) ions have a larger radius, versatile coordination geometry, and high affinity to ligands/drugs containing oxygen or hybrid oxygen-nitrogen atoms. Antenna effect, which is intramolecular energy transfer from the excited triplet states of ligand (donor) to emitting level of Tb ion (acceptor) in chelates leads to a strong narrow-band fluorescence with a large stokes shift, high quantum yields, and long decay times. Tb-drug complexes are of great importance regarding development of sensitive and selective detection methods for determination of drugs in biological samples and dosage forms, especially in combination with nanoparticles. Although, a lot of studies have been published on lanthanide- sensitized based systems, there are only limited reports about application of these systems for determination of pharmaceuticals in biological matrices. Therefore, this review study was conducted to focus on almost all Tb sensitized based-optical sensors/nanosensors developed for determination of pharmaceuticals during 2005−2019. The reported sensors/nanosensors are classified into two types of fluorescence and chemiluminescence-based sensors/nanosensors. Details of each reported study were carefully explained and relevant analytical parameters of the developed methods were also tabulated. © 2020 Taylor & Francis Group, LLC.
Related Docs
1. Optical Sensors Based on Silver Nanoparticles for Determination of Pharmaceuticals: An Overview of Advances in the Last Decade, Talanta (2020)
2. Developing an Analytical Method Based on Graphene Quantum Dots for Quantification of Deferiprone in Plasma, Journal of Fluorescence (2020)
3. Noble Metal Nanoparticles in Biosensors: Recent Studies and Applications, Nanotechnology Reviews (2017)