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Microbial Metabolite Effects on Tlr to Develop Autoimmune Diseases Publisher



Mohseni Moghadam Z1 ; Mahmoodzadeh Hosseini H1 ; Amin M2 ; Behzadi E3 ; Imani Fooladi AA1
Authors
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Authors Affiliations
  1. 1. Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, College of Basic Sciences, Islamic Azad University, Shahr-e-Qods Branch, Tehran, Iran

Source: Toxin Reviews Published:2019


Abstract

The mammalians harbor and are exposed to various populations of microorganisms, that interact with the immune system and are able to affect the balance of immune responses. Modifications of commensal flora can result in dysregulation of immune responses. Toll-like receptors (TLRs) are not only of importance in eliciting the immune responses against pathogens, but also show a significant role in the homeostasis of commensal microbiota and in the response to hazard signals and stress. Here, we review a summary of the TLRs function and the relationship between the immune system and the microbiome in autoimmune diseases' development. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
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