Additive Manufacture of Pcl/Nha Scaffolds Reinforced With Biodegradable Continuous Fibers: Mechanical Properties, In-Vitro Degradation Profile, and Cell Study Publisher



Hedayati SK¹ ; Behravesh AH¹ ; Hasannia S^{2, 3} ; Kordi O¹ ; Pourghaumi M¹ ; Saed AB¹ ; Gashtasbi F³ Show Affiliations
Source: European Polymer Journal Published:2022

Abstract

In this study, an innovative method of “in-situ impregnation” was implemented in the Fused Deposition Modeling (FDM) process to produce poly (∊‐caprolactone) (PCL) scaffolds with enhanced mechanical and biological properties utilizing continuous biodegradable polyglycolic acid (PGA) suture yarns. The study aimed to introduce composite scaffolds, having a nominal porosity of 60% and 0°/60°/120° fibers layout, with tunable mechanical and biological properties for tissue engineering applications. Three different fiber volume contents (15, 25, and 35 vol%) were successfully embedded in the specimens during printing. To enhance the compressive properties, nano‐hydroxyapatite (nHA) was added to the PCL matrix in three levels (0, 10, and 20 wt%). Degradation behaviors of both tensile and compression specimens were also assessed in DMEM and Sorensen buffer. The biological properties of the scaffolds, including surface morphology, biocompatibility, and cell adhesion, were also evaluated. According to the results, incorporating the PGA fibers and nHA particles remarkably enhanced mechanical properties, degradation, and cell adhesion. Also, the composite scaffolds exhibited superior water uptake and hydrophilicity compared to the non-reinforced ones. The results suggest that the introduced 3D printed composite can be produced as a suitable material for bone tissue engineering and resorbable barrier membrane with the desired properties. © 2021 Elsevier Ltd