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Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities Publisher



Sarvizadeh M1 ; Hasanpour O2 ; Naderi Ghalenoie Z3 ; Mollazadeh S4 ; Rezaei M5 ; Pourghadamyari H6 ; Masoud Khooy M7 ; Aschner M8 ; Khan H9 ; Rezaei N10, 11, 12 ; Shojaie L13 ; Mirzaei H14
Authors
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Authors Affiliations
  1. 1. Nutrition and Endocrine Research Centre, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  5. 5. Department of Diabetes, Obesity and Metabolism, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  6. 6. Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Agronomy, Science and Research Branch, Ahvaz Islamic Azad University, Ahvaz, Iran
  8. 8. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States
  9. 9. Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
  10. 10. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  13. 13. Department of Medicine, Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
  14. 14. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Frontiers in Oncology Published:2021


Abstract

Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds in garlic, allicin has been most researched, as it contains sulfur and produces many second degradation compounds, such as sulfur dioxide, diallyl sulfide (DAS), diallyl trisulfide (DATS), and diallyl disulfide (DADS) in the presence of enzymatic reactions in gastric juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, and anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, and skin cancers. Herein, we summarize the therapeutic potential of allicin in the treatment of GI cancers. © Copyright © 2021 Sarvizadeh, Hasanpour, Naderi Ghale-Noie, Mollazadeh, Rezaei, Pourghadamyari, Masoud Khooy, Aschner, Khan, Rezaei, Shojaie and Mirzaei.
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