Allium Vegetables Intake and the Risk of Gastric Cancer in the Stomach Cancer Pooling (Stop) Project Publisher Pubmed



Dalmartello M¹ ; Turati F^{1, 2} ; Zhang ZF³ ; Lunet N^{4, 5, 6} ; Rota M⁷ ; Bonzi R¹ ; Galeone C⁸ ; Martimianaki G^{1, 9} ; Palli D¹⁰ ; Ferraroni M¹ ; Yu GP¹¹ ; Morais S^{4, 5, 6} ; Malekzadeh R¹² ; Lopezcarrillo L¹³ Show All Authors Show Affiliations
Source: British Journal of Cancer Published:2022

Abstract

Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the “Stomach cancer Pooling (StoP) Project”, including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56–0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55–0.86) for onions and 0.83 (95% CI, 0.75–0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29–0.86) but not European (OR 0.96, 95% CI, 0.81–1.13) and American (OR 0.66, 95% CI, 0.39–1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.