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Phytochemicals As Potent Modulators of Autophagy for Cancer Therapy Publisher Pubmed



Moosavi MA1 ; Haghi A2 ; Rahmati M3 ; Taniguchi H4 ; Mocan A5 ; Echeverria J6 ; Gupta VK7 ; Tzvetkov NT8, 9 ; Atanasov AG4, 10
Authors
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Authors Affiliations
  1. 1. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, P.O Box:14965/161, Tehran, Iran
  2. 2. Young Researchers & Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  3. 3. Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, 05-552, Poland
  5. 5. Department of Pharmaceutical Botany, “Iuliu Hatieganu� University of Medicine and Pharmacy, Gheorghe Marinescu 23 Street, 400337, Cluj-Napoca, Romania
  6. 6. Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, 9170022, Chile
  7. 7. Department of Chemistry and Biotechnology, Tallinn University of Technology, ERA Chair of Green Chemistry, Tallinn, 12618, Estonia
  8. 8. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn, 53121, Germany
  9. 9. NTZ Lab Ltd., Krasno Selo 198, Sofia, 1618, Bulgaria
  10. 10. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna, 1090, Austria

Source: Cancer Letters Published:2018


Abstract

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy. © 2018 Elsevier B.V.
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