Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Phytochemicals As Potent Modulators of Autophagy for Cancer Therapy Publisher Pubmed



Moosavi MA1 ; Haghi A2 ; Rahmati M3 ; Taniguchi H4 ; Mocan A5 ; Echeverria J6 ; Gupta VK7 ; Tzvetkov NT8, 9 ; Atanasov AG4, 10
Authors

Source: Cancer Letters Published:2018


Abstract

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy. © 2018 Elsevier B.V.
Other Related Docs
8. Novel Therapeutic Strategies for Stroke: The Role of Autophagy, Critical Reviews in Clinical Laboratory Sciences (2019)
17. The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (Aml)?, International Journal of Hematology-Oncology and Stem Cell Research (2022)
19. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)