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The Role of 18F-Fdg Pet/Mri in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Ghanikolahloo M1 ; Taher HJ2 ; Abdullah AD3 ; Asadi Anar M4 ; Tayebi A5 ; Rahimi R6 ; Olamaeian F5 ; Rahimikashkooli N7 ; Kargar N7
Authors
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Authors Affiliations
  1. 1. King’s College Hospital, London, United Kingdom
  2. 2. Department of Radiology, Hilla University College, Babylon, Iraq
  3. 3. Radiology Technology Department, Al-Manara College for Medical Sciences, Missan, Iraq
  4. 4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Firoozabadi Clinical Research Development Unit (FACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  6. 6. Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (IUMS), Tehran, Iran
  7. 7. Internal Medicine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Radiation Oncology Published:2024


Abstract

Background and aim: The present study aimed to evaluate the use of 18F-2-[18F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone. Methods: We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models. Additionally, we calculated study heterogeneity using the chi-squared test and I2 index and utilized funnel plots and Egger tests to assess publication bias. Results: The current investigation analyzed 239 patients from six published studies. The pooled estimated sensitivity and specificity of 18F-FDG PET/MRI was 0.91 (95% CI = 0.90 to 0.92, I2 = 100% and P = 0.000) and 0.62 (95% CI = 0.53 to 0.72, I2 = 99.8% and P = 0.000), respectively. Pooled sensitivity and specificity of MRI were 0.78 (95%CI = 0.59 to 0.96, I2 = 100% and P = 0.000) and 0.56 (95%CI = 0.33 to 0.80, I2 = 99.8% and P = 0.000), respectively. Conclusions: Based on our findings, the combined form of 18F-FDG PET/MRI imaging is more sensitive and specific than MRI alone for predicting response to NAC in BC patients. © The Author(s) 2024.
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