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Emerging Advances of Nanotechnology in Drug and Vaccine Delivery Against Viral Associated Respiratory Infectious Diseases (Varid) Publisher Pubmed



Seyfoori A1, 2 ; Barough MS3, 4 ; Mokarram P5, 6 ; Ahmadi M7 ; Mehrbod P8 ; Sheidary A9 ; Madrakian T7, 9 ; Kiumarsi M10 ; Walsh T1 ; Mcalinden KD11 ; Ghosh CC12 ; Sharma P13 ; Zeki AA14, 15 ; Ghavami S6, 10, 16, 17 Show All Authors
Authors
  1. Seyfoori A1, 2
  2. Barough MS3, 4
  3. Mokarram P5, 6
  4. Ahmadi M7
  5. Mehrbod P8
  6. Sheidary A9
  7. Madrakian T7, 9
  8. Kiumarsi M10
  9. Walsh T1
  10. Mcalinden KD11
  11. Ghosh CC12
  12. Sharma P13
  13. Zeki AA14, 15
  14. Ghavami S6, 10, 16, 17
  15. Akbari M1, 18, 19
Show Affiliations
Authors Affiliations
  1. 1. Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, V8P 5C2, BC, Canada
  2. 2. Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  3. 3. Department of Immunology, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  4. 4. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  5. 5. Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran
  6. 6. Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran
  7. 7. Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838695, Iran
  8. 8. Influenza and Respiratory Viruses Department, Pasteur Institute of IRAN, Tehran, 1316943551, Iran
  9. 9. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
  10. 10. Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, R3E 0J9, MB, Canada
  11. 11. Department of Laboratory Medicine, School of Health Sciences, University of Tasmania, Launceston, 7248, TAS, Australia
  12. 12. Roger Williams Medical Center, Immuno-Oncology Institute (Ix2), Providence, 02908, RI, United States
  13. 13. Center for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 19107, PA, United States
  14. 14. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, U.C. Davis Lung Center, Davis School of Medicine, University of California, Davis, Davis, 95817, CA, United States
  15. 15. Veterans Affairs Medical Center, Mather, 95817, CA, United States
  16. 16. Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, R3E 0J9, MB, Canada
  17. 17. Research Institute of Oncology and Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, R3E 0J9, MB, Canada
  18. 18. Biotechnology Center, Silesian University of Technology, Akademicka 2A, Gliwice, 44-100, Poland
  19. 19. Center for Advanced Materials and Related Technologies, University of Victoria, Victoria, V8P 5C2, BC, Canada

Source: International Journal of Molecular Sciences Published:2021


Abstract

Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting the respiratory system. For the past 100 years, viral associated respiratory epidemics have been the most common cause of infectious disease worldwide. Due to several drawbacks of the current anti-viral treatments, such as drug resistance generation and non-targeting of viral proteins, the development of novel nanotherapeutic or nano-vaccine strategies can be considered essential. Due to their specific physical and biological properties, nanoparticles hold promising opportunities for both anti-viral treatments and vaccines against viral infections. Besides the specific physiological properties of the respiratory system, there is a significant demand for utilizing nano-designs in the production of vaccines or antiviral agents for airway-localized administration. SARS-CoV-2, as an immediate example of respiratory viruses, is an enveloped, positive-sense, single-stranded RNA virus belonging to the coronaviridae family. COVID-19 can lead to acute respiratory distress syndrome, similarly to other members of the coronaviridae. Hence, reviewing the current and past emerging nanotechnology-based medications on similar respiratory viral diseases can identify pathways towards generating novel SARS-CoV-2 nanotherapeutics and/or nano-vaccines. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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