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Technology Developments in Biological Tools for Targeted Genome Surgery Publisher Pubmed



Teimourian S1, 2, 3 ; Abdollahzadeh R2
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Human Genetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Infectious Disease, School of Medicine, Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Biotechnology Letters Published:2015


Abstract

Different biological tools for targeted genome engineering have recently appeared and these include tools like meganucleases, zinc-finger nucleases and newer technologies including TALENs and CRISPR/Cas systems. transcription activator-like effector nucleases (TALENs) have greatly improved genome editing efficiency by making site-specific DNA double-strand breaks. Several studies have shown the prominence of TALENs in comparison to the meganucleases and zinc-finger nucleases. The most important feature of TALENs that makes them suitable tools for targeted genome editing is the modularity of central repeat domains, meaning that they can be designed to recognize any desirable DNA sequence. In this review, we present a comprehensive and concise description of TALENs technology developments for targeted genome surgery with to the point description and comparison of other tools. © 2014, Springer Science+Business Media Dordrecht.
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