Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Melatonin Supplementation in Alzheimer’S Disease: The Potential Role in Neurogenesis Publisher



R Ebrahimi RASOUL ; A Faramarzi ALI ; S Salarvandian SHAKIBA ; R Zarei REYHANEH ; M Heidari MOGHADASEH ; F Salehian FATEMEH ; K Esmaeilpourbezenjani K
Authors

Source: Molecular Neurobiology Published:2025


Abstract

Melatonin supplementation shows potential therapeutic effects in Alzheimer’s disease (AD) by targeting impaired neurogenesis. Neurogenesis, the formation of new neurons after development, involves proliferation, migration, differentiation, and survival of neurons. Impaired neurogenesis is associated with AD, specifically in the subventricular zone (SVZ) and subgranular zone (SGZ), leading to hippocampal degeneration and memory impairment. Melatonin positively effects AD by regulating amyloid beta (Aβ)-induced neuroinflammation, reducing tau hyperphosphorylation, and enhancing adult neurogenesis through various signaling pathways. In addition, it has anti-apoptotic, antioxidative, and anti-inflammatory properties, suggesting its potential as a treatment option for AD progression. Furthermore, melatonin and sleep are closely linked, and an increase in sleep duration positively affects Aβ deposition. This review aims to examine the impact of AD pathologies on neurogenesis and explore the mechanisms by which melatonin may alleviate these pathologies, potentially promoting neurogenesis. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Evaluation of Hippocampal Arylalkylamine N-Acetyltransferase Activity in Amyloid-Β Neurotoxicity, Journal of Molecular Endocrinology (2023)
2. Molecular Anti-Inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’S Disease: A Review of Current Evidence, Journal of Molecular Neuroscience (2017)
3. Impaired Memory and Evidence of Histopathology in Ca1 Pyramidal Neurons Through Injection of Aβ1-42 Peptides Into the Frontal Cortices of Rat, Basic and Clinical Neuroscience (2016)
Experts (# of related papers)
View all Related Experts
Maryam Zahmatkesh (3)
Gholamreza Hassanzadeh (2)
Other Related Docs
4. Melatonin Protective Effect Against Amyloid Β-Induced Neurotoxicity Mediated by Mitochondrial Biogenesis; Involvement of Hippocampal Sirtuin-1 Signaling Pathway, Physiology and Behavior (2019)
5. Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease?, Cellular and Molecular Neurobiology (2023)
6. Microrna in Alzheimer's Disease Revisited: Implications for Major Neuropathological Mechanisms, Reviews in the Neurosciences (2018)
7. Modulation of Apoptosis by Melatonin for Improving Cancer Treatment Efficiency: An Updated Review, Life Sciences (2019)
8. Reversal Effects of Crocin on Amyloid Β-Induced Memory Deficit: Modification of Autophagy or Apoptosis Markers, Pharmacology Biochemistry and Behavior (2015)
9. Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective, Pathology Research and Practice (2023)
10. Effects of Combination of Melatonin and L-Carnitine on in Vitro Maturation in Mouse Oocytes: An Experimental Study, International Journal of Reproductive BioMedicine (2024)
11. Parkinson’S Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, Rem Behavior Disorder, and Melatonin, Brain Sciences (2023)
12. The Boosting Effects of Melatonin on the Expression of Related Genes to Oocyte Maturation and Antioxidant Pathways: A Polycystic Ovary Syndrome- Mouse Model, Journal of Ovarian Research (2022)
13. The Correlation of Serum S100β Protein Levels and Hippocampal Seladin-1 Gene Expression in a Rat Model of Sporadic Alzheimer’S Disease, Tehran University Medical Journal (2015)
14. Protective Effects of Flavonoids Against Alzheimer's Disease-Related Neural Dysfunctions, Biomedicine and Pharmacotherapy (2017)
15. Evidence for the Benefits of Melatonin in Cardiovascular Disease, Frontiers in Cardiovascular Medicine (2022)
16. Potential Therapeutic Effects of Melatonin Mediate Via Mirnas in Cancer, Biochemical Genetics (2022)
17. Classification of Early-Mci Patients From Healthy Controls Using Evolutionary Optimization of Graph Measures of Resting-State Fmri, for the Alzheimer’S Disease Neuroimaging Initiative, PLoS ONE (2022)
18. Immunoregulatory Role of Melatonin in Cancer, Journal of Cellular Physiology (2020)
19. Crosstalk Between Alzheimer’S Disease and Diabetes: A Focus on Anti-Diabetic Drugs, Metabolic Brain Disease (2023)
20. Naringenin Improves Learning and Memory in an Alzheimer's Disease Rat Model: Insights Into the Underlying Mechanisms, European Journal of Pharmacology (2015)