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Aspergillus Spondylodiscitis in an Immunocompetent Patient With Recurrent Aspergillus Endocarditis; a Clinical Case Report Publisher



Meidani M1 ; Moradi M2 ; Rahmanian M3 ; Salehi M3 ; Foroumandi M4 ; Larti F5 ; Alijani N6 ; Movahhed H7 ; Rahimi E1 ; Ghiasvand F1
Authors
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Authors Affiliations
  1. 1. Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Eye Research Center, the Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Cardiothoracic Surgery, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Critical Care Medicine, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Infectious Disease and Tropical Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Open Forum Infectious Diseases Published:2025


Abstract

Introduction. Fungal endocarditis is a very uncommon and deadly illness that causes inflammation in the heart’s lining, including the valves. Aspergillus endocarditis is the second most common cause of prosthetic endocarditis, especially the aortic valve, after Candida spp. Aspergillus endocarditis can occur on native and prosthetic valves, even in immunocompetent hosts. Case Report. In this article, we describe a case of recurrent aortic-valve Aspergillus endocarditis occurring in a Caucasian man without previously known immunocompromised status with multiple brain septic emboli and spondylodiscitis. The patient was successfully responsive to liposomal amphotericin B. Discussion. Early recognition in patients with underlying immunosuppressive conditions and immunocompetent hosts is critical to decreasing the mortality rate. Aspergillosis must be considered in every patient with a prior valve replacement history and culture-negative endocarditis. Surgical debridement and appropriate antifungal agents are required to resolve the problem. © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of Americ.