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Cell Therapy Using Embryonic Stem Cell Source in Clinical Trial Studies: Advantages and Limitations



Golchin A1 ; Niknejad H2
Authors
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Authors Affiliations
  1. 1. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Applied cell science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Mazandaran University of Medical Sciences Published:2017

Abstract

Background and purpose: The unique characteristics and potency of stem cells have attracted interest for their use in cell therapy. However, the use of these cells has some limitations and problems such as ethical issues. The aim of this study was to perform a systematic review on the use of embryonic stem cell for clinical therapy targets and investigating its advantages and limitations. Materials and methods: Data was collected from electronic databases including PubMed, Science direct, Medline, Clinical trial.gov, SID, etc. The search keywords included pluripotent stem cell, Embryonic stem cell (eSC), and stem cell therapy. Results: Study of published articles and ongoing studies showed that pluripotency, cell viability and low immunogenicity of eSC are amongst the major reasons for their use. Conclusion: Recent developments in clinical application of eSC make them a major candidate in using stem cells alongside MSC and iPS. But, further studies are needed due to its importance in many aspects. © 2017, Mazandaran University of Medical Sciences. All rights reserved.
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