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The Prevalence of Pulmonary Arterial Hypertension in Patients With Beta Thalassemia Major Publisher



Kahnoji M1 ; Bitaraf S2 ; Soltani N3 ; Esmaeilinadimi H4
Authors
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Authors Affiliations
  1. 1. Cardiovascular Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Science, Kerman, Iran
  2. 2. Department of Epidemiology, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  4. 4. Shariati Hospital, Tehran University of Medical Science, Tehran, Iran

Source: Indian Journal of Hematology and Blood Transfusion Published:2024


Abstract

Pulmonary arterial hypertension (PAH) remains a concern in patients with Beta thalassemia major (TM). However, this study aims to investigate the prevalence of PAH in TM patients in Kerman City placed in the south of Iran. In this cross-sectional study on 271 IranianBeta-thalassemia patients (mean age 19.8 ± 7.9 in the range 10–60), Age, sex, weekly deferral taking, the number of blood transfusion in a month, and last echocardiography report data was gathered from every patient's file. SPSS for Windows (version 21) was used for analysis. According to the results, the prevalence of PAH was 10.3% (28 patients). PAH had significant associations with weekly deferral consumption (P = 0.028), ferritin serum level (P = 0.001), and ejection fraction (EF) (P = 0.001). PAH is positively associated with deferral consumption and is negatively associated with EF (respectively, P = 0.031, P = 0.001). It is very important to consider prevention and treatment for decreasing the mortality and morbidity of PAH patients in health planning and policy. © 2023, The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion.
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