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Cardiovascular Disease Mortality and Years of Life Lost Attributable to Non-Optimal Systolic Blood Pressure and Hypertension in Northeastern Iran Pubmed



Sepanlou SG1 ; Newson RB2 ; Poustchi H1 ; Malekzadeh MM1 ; Rezanejad Asl P1 ; Etemadi A1, 3 ; Khademi H1, 4 ; Islami F1, 5 ; Pourshams A1 ; Pharoah PD6 ; Abnet CC3 ; Brennan P4 ; Bofetta P7 ; Dawsey SM3 Show All Authors
Authors
  1. Sepanlou SG1
  2. Newson RB2
  3. Poustchi H1
  4. Malekzadeh MM1
  5. Rezanejad Asl P1
  6. Etemadi A1, 3
  7. Khademi H1, 4
  8. Islami F1, 5
  9. Pourshams A1
  10. Pharoah PD6
  11. Abnet CC3
  12. Brennan P4
  13. Bofetta P7
  14. Dawsey SM3
  15. Kamangar F1, 8
  16. Malekzadeh R1
Show Affiliations
Authors Affiliations
  1. 1. Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. National Heart and Lung Institute, Imperial College London, United Kingdom
  3. 3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
  4. 4. International Agency for Research on Cancer, Lyon, France
  5. 5. Surveillance and Health Services Research, American Cancer Society, Atlanta, United States
  6. 6. Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  7. 7. The Tisch Cancer Institute, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  8. 8. Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, United States

Source: Archives of Iranian Medicine Published:2015


Abstract

Background: High blood pressure is the second most important risk factor of cardiovascular diseases (CVDs) in Iran. It is imperative to estimate the burden of CVDs that can be averted if high blood pressure is controlled at the population level. The aim of the current study was to estimate the avertable CVD mortality in the setting of Golestan Cohort Study (GCS). Methods: Over 50,000 participants were recruited and followed for a median of 7 years. The exposures of interest in this study were non-optimal systolic blood pressure (SBP) and hypertension measured at baseline. Deaths by cause have been precisely recorded. The Population Attributable Fraction (PAF) of deaths and Years of Life Lost (YLLs) due to CVDs attributable to exposures of interest were calculated. Results: Overall, 223 deaths due to ischemic heart disease (IHD), 207 deaths due to cerebrovascular accidents (CVA), and 460 deaths due to all CVDs could be averted if the SBP of all subjects in the study were optimal. Similarly, 5,560 YLLs due to IHD, 4,771 YLLs due to CVA, and 11,135 YLLs due to CVDs could be prevented if SBP were optimal. In all age groups, the avertable deaths and YLLs were higher due to IHD compared with CVA. Deaths and YLLs attributable to non-optimal SBP in women were less than men Conclusions: A very large proportion of CVD deaths can be averted if blood pressure is controlled in Iran. Effective interventions in primary and secondary health care setting are mandatory to be implemented as early as possible. © 2015, Academy of Medical Sciences of I.R. Iran. All rights reserved.
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