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Dermoscopy Features of Atypical Fibroxanthoma: A Multicenter Study of the International Dermoscopy Society Publisher Pubmed



Moscarella E1, 2 ; Piana S3 ; Specchio F1, 2 ; Kyrgidis A1 ; Nazzaro G4 ; Eliceche ML5 ; Savoia F6 ; Bugatti L7 ; Filosa G7 ; Zalaudek I8 ; Scarfi F9 ; Inskip M10 ; Rosendahl C11, 12 ; Pyne JH11 Show All Authors
Authors
  1. Moscarella E1, 2
  2. Piana S3
  3. Specchio F1, 2
  4. Kyrgidis A1
  5. Nazzaro G4
  6. Eliceche ML5
  7. Savoia F6
  8. Bugatti L7
  9. Filosa G7
  10. Zalaudek I8
  11. Scarfi F9
  12. Inskip M10
  13. Rosendahl C11, 12
  14. Pyne JH11
  15. Siggs G13
  16. Togral AK14
  17. Cabo H15
  18. Drlik L16
  19. Lallas A17
  20. Longo C1, 18
  21. Argenziano G2
Show Affiliations
Authors Affiliations
  1. 1. Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy
  2. 2. Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy
  3. 3. Pathology Unit, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy
  4. 4. Department of Physiopathology and Transplantation, University of Milan, UOC Dermatologia, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  5. 5. Dermatology Unit, Italian Hospital of Buenos Aires, Buenos Aires, Argentina
  6. 6. Unit of Dermatology, AUSL Ravenna, Ravenna, Italy
  7. 7. Dermatology Unit, ‘Carlo Urbani’ Hospital, Jesi, Italy
  8. 8. Dermatology Clinic, University of Trieste, Hospital Maggiore, Trieste, Italy
  9. 9. Dermatology Unit, University of Florence, Florence, Italy
  10. 10. Skin Patrol Skin Cancer Clinic, Melbourne, VIC, Australia
  11. 11. School of Medicine, University of Queensland, Brisbane, QLD, Australia
  12. 12. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. SunDoctors Skin Cancer Clinic, Adelaide, SA, Australia
  14. 14. Faculty of Medicine, Department of Dermatology, Baskent University, Ankara, Turkey
  15. 15. Dermatology Unit, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
  16. 16. Department of Dermatology, Sumperk Hospital, Sumperk, Czech Republic
  17. 17. First Department of Dermatology, Aristotle University, Thessaloniki, Greece
  18. 18. Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy

Source: Australasian Journal of Dermatology Published:2018


Abstract

Background/Objectives: Little is known about the dermoscopic features of atypical fibroxanthoma. Methods: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Results: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles. Conclusions: Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis. © 2018 The Australasian College of Dermatologists
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