Tehran University of Medical Sciences

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Whole Tumor Cell Vaccine for Cancer Publisher



Razi S1, 2 ; Keshavarzfathi M1, 3, 4
Authors

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2019


Abstract

Cancer vaccines, which are a type of immunotherapeutic agents, have been widely studied for prevention and treatment of tumors. Therapeutic cancer vaccines improve patient's immune response against tumor cells. One of the several types of cancer vaccines is whole tumor cell vaccine. Whole tumor cell vaccines, which consist of allogeneic or autologous tumor cells or tumor cell lines, contain a large variety of characterized and uncharacterized tumor-associated antigens that could activate antitumor immune reactions. There are several methods for preparation of these vaccines such as tumor cell lysates, tumor-derived exosomes, and irradiated gene-modified tumor cell lines. This chapter will briefly describe the clinical trials, advantages and disadvantages of these vaccines and will discuss some ways that can help to optimize these vaccines. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd. All rights reserved.
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