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Zeolites in Drug Delivery: Progress, Challenges and Opportunities Publisher Pubmed



Servatan M1 ; Zarrintaj P2 ; Mahmodi G2 ; Kim SJ2 ; Ganjali MR3, 4 ; Saeb MR5 ; Mozafari M6
Authors
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Authors Affiliations
  1. 1. Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, Iran
  2. 2. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States
  3. 3. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  4. 4. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Departments of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran
  6. 6. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

Source: Drug Discovery Today Published:2020


Abstract

There are continuing attempts to achieve appropriate controlled-release therapeutic systems by designing innovative functional drug delivery systems (DDS). Although various types of delivery system have been developed, strategies that have successfully made it to the clinic are rare. Given their diverse structures, zeolites have attracted significant research attention for controlled and targeted drug delivery purposes. The structure of zeolites can be microporous, mesoporous or macroporous, which can be exploited to deliver a variety of therapeutic agents to the target site in a controlled manner. In this review, we introduce the different types of zeolite, and discuss the challenges and opportunities associated with their usage as drug delivery systems. © 2020 Elsevier Ltd; Zeolites are a focus of research in drug discovery because of their adjustable pore and surface features, which could be exploited for tunable/controlled drug delivery. © 2020 Elsevier Ltd
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