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Thermo-Sensitive Polymers in Medicine: A Review Publisher



Zarrintaj P1, 2, 3 ; Jouyandeh M3, 4 ; Ganjali MR4, 5 ; Hadavand BS6 ; Mozafari M7 ; Sheiko SS8 ; Vatankhahvarnoosfaderani M8 ; Gutierrez TJ9 ; Saeb MR3, 4, 6
Authors
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Authors Affiliations
  1. 1. Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, Iran
  2. 2. Color and Polymer Research Center (CPRC), Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran
  3. 3. Advanced Materials Group, Iranian Color Society (ICS), P.O. Box 1591637144, Tehran, Iran
  4. 4. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  5. 5. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences, Iran
  6. 6. Department of Resin and Additives, Institute for Color Science and Technology, P.O. Box: 16765-654, Tehran, Iran
  7. 7. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  8. 8. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  9. 9. Grupo de Materiales Compuestos Termoplasticos (CoMP), Instituto de Investigaciones en Ciencia y Tecnologia de Materiales (INTEMA), Facultad de Ingenieria, Universidad Nacional de Mar del Plata (UNMdP)y Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Colon 10850, B7608FLC, Mar del Plata, Argentina

Source: European Polymer Journal Published:2019


Abstract

A wide variety of smart polymer systems such as thermosensitive polymers (TSPs)have been developed and applied mimicking nature. TSPs are a class of macromolecules that exhibit bio-inspired behavior and have various applications such as drug delivery, tissue engineering, theranostic particles and bioseparation. An inherent feature of a living system is its ability to react in response to an external stimulus. The temperature dependence of polymer properties is the reason behind dramatic changes in morphology, solubility, shape and sol-gel transition. TSPs can be synthesized as hydrogel, micro- and nanoparticles, film, micelle and mussel-inspired materials. The architecture of TSPs determines their biomimetic patterns and allows one to expand their uses. TSPs can be used as systems for the controlled release of drugs to a specific organ, as well as scaffolds in tissue engineering. Multi-responsive and thermosensitive features of TSPs give rise to design of smart systems for special applications. For example, pH- and photo-responsive abilities in combination with temperature sensitivity can play a vital role in drug delivery and tissue engineering. In-depth knowledge about the structure-property relationship is a key factor to design a smart biomimetic polymer. In this review paper, the functional design of the TSPs, their biomedical applications and the road ahead for their developments are comprehensively overviewed. © 2019 Elsevier Ltd
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