Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]

Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد] Publisher

Doosti R¹ ; Kohandel K¹ ; Shabestari HF¹ ; Vahabizad F² ; Azimi A²

Show Affiliations

1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Multiple Sclerosis Research Center, Neuroscience Institute And Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Isfahan Medical School Published:2023

Abstract

Background: Autosomal dominant cerebral arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) is a genetic vascular disorder clinically characterized by migraine, transient ischemic attacks (TIA) and cognitive deficits and it is caused by mutations in the NOTCH3 gene. Case Report: The presented case is a patient with magnetic resonance imaging (MRI) and atypical clinical findings, which was misdiagnosed as multiple sclerosis (MS) for several years, the patient was referred to our service due to recurrent neurological deficits. MRI examinations and gene analysis were done for them. MRI showed extensive hyperintensity in T2 and fluid-attenuated inversion recovery (FLAIR) and multiple small hemorrhages in susceptibility-weighted imaging (SWI) in the periventricular region, external capsule, and anterior temporal lobe. Genetic analysis of the NOTCH3 gene confirmed the diagnosis of CADASIL. Once CADASIL was confirmed, MS-related treatments were discontinued. Conclusion: The presented case underscores the importance of carefully evaluation of clinical findings and neuroimaging in suspected MS patients and emphasizes the importance of CADASIL as an overlooked differential diagnosis. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.

Style	Citing Format
MLA	Doosti R, et al.. "Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]." Journal of Isfahan Medical School, vol. 41, no. 721, 2023, pp. 401-405.
APA	Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A (2023). Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]. Journal of Isfahan Medical School, 41(721), 401-405.
Chicago	Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A. "Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]." Journal of Isfahan Medical School 41, no. 721 (2023): 401-405.
Harvard	Doosti R et al. (2023) 'Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]', Journal of Isfahan Medical School, 41(721), pp. 401-405.
Vancouver	Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A. Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]. Journal of Isfahan Medical School. 2023;41(721):401-405.
BibTex	@article{ author = {Doosti R and Kohandel K and Shabestari HF and Vahabizad F and Azimi A}, title = {Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]}, journal = {Journal of Isfahan Medical School}, volume = {41}, number = {721}, pages = {401-405}, year = {2023} }
RIS	TY - JOUR AU - Doosti R AU - Kohandel K AU - Shabestari HF AU - Vahabizad F AU - Azimi A TI - Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد] JO - Journal of Isfahan Medical School VL - 41 IS - 721 SP - 401 EP - 405 PY - 2023 ER -

Style

Citing Format

MLA

Doosti R, et al.. "Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]." Journal of Isfahan Medical School, vol. 41, no. 721, 2023, pp. 401-405.

APA

Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A (2023). Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]. Journal of Isfahan Medical School, 41(721), 401-405.

Chicago

Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A. "Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]." Journal of Isfahan Medical School 41, no. 721 (2023): 401-405.

Harvard

Doosti R et al. (2023) 'Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]', Journal of Isfahan Medical School, 41(721), pp. 401-405.

Vancouver

Doosti R, Kohandel K, Shabestari HF, Vahabizad F, Azimi A. Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]. Journal of Isfahan Medical School. 2023;41(721):401-405.

BibTex

@article{ author = {Doosti R and Kohandel K and Shabestari HF and Vahabizad F and Azimi A}, title = {Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]}, journal = {Journal of Isfahan Medical School}, volume = {41}, number = {721}, pages = {401-405}, year = {2023} }

RIS

TY - JOUR
AU - Doosti R
AU - Kohandel K
AU - Shabestari HF
AU - Vahabizad F
AU - Azimi A
TI - Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد]
JO - Journal of Isfahan Medical School
VL - 41
IS - 721
SP - 401
EP - 405
PY - 2023
ER -

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