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Enhancement of the Peroxidase-Like Activity of Cerium-Doped Ferrite Nanoparticles for Colorimetric Detection of H2o2 and Glucose Publisher



Hosseini M1 ; Sadat Sabet F1 ; Khabbaz H1 ; Aghazadeh M2 ; Mizani F3 ; Ganjali MR2, 4
Authors

Source: Analytical Methods Published:2017


Abstract

In this report, cerium doped-ferrite nanoparticles (Ce-Fe3O4 NPs), a novel ceria nanostructure, were proposed to have intrinsic peroxidase-like activity toward a classic peroxidase substrate in the presence of H2O2. The peroxidase-like activity of ceria originated from its facile redox behavior (Ce3+/Ce4+) as a catalytic center, thereby explaining the high performance of ferrite-ceria as an artificial enzyme mimicking peroxidase. The as-prepared Ce-Fe3O4 NPs were first demonstrated to possess intrinsic peroxidase-like activity, enhancing the oxidation of the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of either added H2O2 or H2O2 produced by the enzymatic oxidation of glucose, producing a blue product which could be seen by the naked eye. Based on this, we have successfully established a novel platform for the colorimetric detection of H2O2 with a detection limit of 0.6 μM. Furthermore, the Ce-Fe3O4 NP-based platform can also be used for highly sensitive and selective detection of glucose with a linear range of 5.0-150.0 μM and a detection limit of 1.2 μM. © The Royal Society of Chemistry 2017.
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