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Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide Publisher



Saeedi M1, 2 ; Hashemi M3 ; Mahdavi M4 ; Rafinejad A3 ; Najafi Z5 ; Mirfazli SS6 ; Mohammadian R7 ; Karimpourrazkenari E2 ; Kabudanian Ardestani S7 ; Safavi M8 ; Akbarzadeh T2, 3
Authors

Source: Polycyclic Aromatic Compounds Published:2020


Abstract

In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage. © 2019 Taylor & Francis Group, LLC.
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