Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents

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Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents Publisher Pubmed

Khalili F¹ ; Akrami S² ; Safavi M³ ; Mohammadikhanaposhtani M⁴ ; Saeedi M^{5, 6} ; Ardestani SK¹ ; Larijani B⁷ ; Zonouzi A² ; Tehrani MB⁸ ; Mahdavi M⁷

Source: Anti-Cancer Agents in Medicinal Chemistry Published:2019

Abstract

Background: This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel series of styrylimidazo[1,2-a]pyridine derivatives. Objective: In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated. Methods: Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism of cell death Results: Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide. Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned methods. Conclusion: In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug discovery developments in the field of anti-cancer agents. © 2019 Bentham Science Publishers.

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Style	Citing Format
MLA	Khalili F, et al.. "Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents." Anti-Cancer Agents in Medicinal Chemistry, vol. 19, no. 2, 2019, pp. 265-275.
APA	Khalili F, Akrami S, Safavi M, Mohammadikhanaposhtani M, Saeedi M, Ardestani SK, Larijani B, Zonouzi A, Tehrani MB, Mahdavi M (2019). Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry, 19(2), 265-275.
Chicago	Khalili F, Akrami S, Safavi M, Mohammadikhanaposhtani M, Saeedi M, Ardestani SK, Larijani B, Zonouzi A, Tehrani MB, Mahdavi M. "Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents." Anti-Cancer Agents in Medicinal Chemistry 19, no. 2 (2019): 265-275.
Harvard	Khalili F et al. (2019) 'Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents', Anti-Cancer Agents in Medicinal Chemistry, 19(2), pp. 265-275.
Vancouver	Khalili F, Akrami S, Safavi M, Mohammadikhanaposhtani M, Saeedi M, Ardestani SK, et al.. Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry. 2019;19(2):265-275.
BibTex	@article{ author = {Khalili F and Akrami S and Safavi M and Mohammadikhanaposhtani M and Saeedi M and Ardestani SK and Larijani B and Zonouzi A and Tehrani MB and Mahdavi M}, title = {Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents}, journal = {Anti-Cancer Agents in Medicinal Chemistry}, volume = {19}, number = {2}, pages = {265-275}, year = {2019} }
RIS	TY - JOUR AU - Khalili F AU - Akrami S AU - Safavi M AU - Mohammadikhanaposhtani M AU - Saeedi M AU - Ardestani SK AU - Larijani B AU - Zonouzi A AU - Tehrani MB AU - Mahdavi M TI - Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents JO - Anti-Cancer Agents in Medicinal Chemistry VL - 19 IS - 2 SP - 265 EP - 275 PY - 2019 ER -

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