Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents Publisher Pubmed



Khalili F1 ; Akrami S2 ; Safavi M3 ; Mohammadikhanaposhtani M4 ; Saeedi M5, 6 ; Ardestani SK1 ; Larijani B7 ; Zonouzi A2 ; Tehrani MB8 ; Mahdavi M7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  3. 3. Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
  4. 4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  5. 5. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Anti-Cancer Agents in Medicinal Chemistry Published:2019


Abstract

Background: This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel series of styrylimidazo[1,2-a]pyridine derivatives. Objective: In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated. Methods: Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism of cell death Results: Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide. Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned methods. Conclusion: In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug discovery developments in the field of anti-cancer agents. © 2019 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Design, Synthesis and in Vitro Cytotoxicity of New 1,2,3-Triazol-And Nitrostyrene Hybrids As Potent Anticancer Agents, Letters in Drug Design and Discovery (2018)
2. New Biscoumarin Derivatives As Potent Α-Glucosidase Inhibitors: Synthesis, Biological Evaluation, Kinetic Analysis, and Docking Study, Polycyclic Aromatic Compounds (2020)
3. Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents, Letters in Drug Design and Discovery (2019)
4. Design, Synthesis and in Vitro Α-Glucosidase Inhibition of Novel Dihydropyrano[3,2-C]Quinoline Derivatives As Potential Anti-Diabetic Agents, Bioorganic Chemistry (2018)
5. Pyrano[3,2-C]Quinoline Derivatives As New Class of Α-Glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in Vitro Biological Evaluation and Kinetic Study, Medicinal Chemistry (2019)
6. Design, Synthesis, Docking Study, Α-Glucosidase Inhibition, and Cytotoxic Activities of Acridine Linked to Thioacetamides As Novel Agents in Treatment of Type 2 Diabetes, Bioorganic Chemistry (2018)
7. Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Apoptosis-Induction Study of New 9(10H-Acridinone-1,2,3-Triazoles, Molecular Diversity (2015)
8. Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico, Chemistry and Biodiversity (2018)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (12)
Bagher Larijani (8)
Other Related Docs
9. Design and Synthesis of New Imidazo[1,2-B]Pyrazole Derivatives, in Vitro Α-Glucosidase Inhibition, Kinetic and Docking Studies, Molecular Diversity (2020)
10. Anticancer Effects of Synthetic Hexahydrobenzo [G]Chromen-4-One Derivatives on Human Breast Cancer Cell Lines, Breast Cancer (2017)
11. Culture Strategy As a Modulator of Target Assessments: Functionality of Suspension Versus Hanging Drop-Derived Choriocarcinoma Spheroids As in Vitro Model of Embryo Implantation, Journal of Cellular Biochemistry (2021)
12. Synthesis and Cytotoxic Activity of Novel Poly-Substituted Imidazo[2,1-C][1,2,4]Triazin-6-Amines, Molecular Diversity (2015)
13. Antagonistic Effect of Co-Exposure to Short-Multiwalled Carbon Nanotubes and Benzo[A]Pyrene in Human Lung Cells (A549), Toxicology and Industrial Health (2019)
14. Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide, Polycyclic Aromatic Compounds (2020)
15. Design and Synthesis of Novel Quinazolinone-1,2,3-Triazole Hybrids As New Anti-Diabetic Agents: In Vitro Α-Glucosidase Inhibition, Kinetic, and Docking Study, Bioorganic Chemistry (2019)
16. Apoptosis Induction and Proliferation Inhibition by Silibinin Encapsulated in Nanoparticles in Mia Paca-2 Cancer Cells and Deregulation of Some Mirnas, Iranian Journal of Basic Medical Sciences (2020)
17. Xanthohumol Hinders Invasion and Cell Cycle Progression in Cancer Cells Through Targeting Mmp2, Mmp9, Fak and P53 Genes in Three-Dimensional Breast and Lung Cancer Cells Culture, Cancer Cell International (2023)