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Polysaccharide-Based Hydrogels Containing Herbal Extracts for Wound Healing Applications Publisher Pubmed



Abazari M1 ; Akbari T2 ; Hasani M3 ; Sharifikolouei E4 ; Raoufi M5 ; Foroumadi A6 ; Sharifzadeh M7 ; Firoozpour L5 ; Khoobi M8, 9
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  2. 2. Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran
  3. 3. Zanjan Pharmaceutical Nanotechnology Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  4. 4. Department of Applied Science and Technology, Politecnico di Torino, Corso Duca Degli Abruzzi 24, Turin, 10129, TO, Italy
  5. 5. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
  6. 6. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
  7. 7. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Carbohydrate Polymers Published:2022


Abstract

Development of an ideal wound dressing with effective function for healing various types of wounds is the ultimate desire of the researchers. Natural-based compounds such as polysaccharides and phytochemicals offer useful properties making them perfect candidates for wound management. Polysaccharides-based hydrogels with an interconnected three-dimensional network, and desired properties have great potential as a carrier for delivery of different herbal extracts for oral and topical applications. Herbal extracts are extensively used for wound healing purposes, individually or in combination with other active agents. This study summarizes the current knowledge acquired on the preparation, functionalizing, and application of different kinds of polysaccharide-based hydrogels enriched by herbal extracts for different wound healing applications. The structural, biological, and functional impact of the polysaccharides and herbal extracts on the final hydrogel characteristics, as well as their influence on the different phases of the wound healing process have been discussed. © 2022 Elsevier Ltd