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Recent Approaches to Mrna Vaccine Delivery by Lipid-Based Vectors Prepared by Continuous-Flow Microfluidic Devices Publisher Pubmed



Toudeshkchouei MG1 ; Tavakoli A2 ; Mohammadghasemi H8 ; Karimi A3 ; Ai J4 ; Rabiee M5 ; Rabiee N6, 7
Authors
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Authors Affiliations
  1. 1. Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran
  2. 2. School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155/4563, Tehran, Iran
  3. 3. Department of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biomedical Engineering, Biomaterial Group, Amirkabir University of Technology, Tehran, Iran
  6. 6. Department of Physics, Sharif University of Technology, Tehran, Iran
  7. 7. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia
  8. 8. Department of Chemical and Materials Engineering, University of Alberta, Edmonton, T6G 2V4, AB, Canada

Source: Future Medicinal Chemistry Published:2022


Abstract

Advancements in nanotechnology have resulted in the introduction of several nonviral delivery vectors for the nontoxic, efficient delivery of encapsulated mRNA-based vaccines. Lipid- and polymer-based nanoparticles (NP) have proven to be the most potent delivery systems, providing increased delivery efficiency and protection of mRNA molecules from degradation. Here, the authors provide an overview of the recent studies carried out using lipid NPs and their functionalized forms, polymeric and lipid-polymer hybrid nanocarriers utilized mainly for the encapsulation of mRNAs for gene and immune therapeutic applications. A microfluidic system as a prevalent methodology for the preparation of NPs with continuous flow enables NP size tuning, rapid mixing and production reproducibility. Continuous-flow microfluidic devices for lipid and polymeric encapsulated RNA NP production are specifically reviewed. © 2022 Newlands Press.
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