Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Recent Advances in Sirna Delivery Systems for Prostate Cancer Therapy Publisher Pubmed



Aghamiri S1, 2 ; Raee P3 ; Shahmohamadnejad S4 ; Shabani S5 ; Ghorbani J6 ; Sameni M7 ; Ebrahimi MT7
Authors

Source: Current Pharmaceutical Biotechnology Published:2022


Abstract

The critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nano-particle-based siRNA therapeutics. Unfortunately, siRNA-based therapeutics suffer from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manufacturing, clinical translation, and commercialization. In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a revolutionary robust strategy for prostate cancer combinational therapy is completely covered. © 2022 Bentham Science Publishers.
Other Related Docs
16. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)