The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer

The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer Pubmed

Saffari M^{1, 2} ; Ghaderian SMH³ ; Omrani MD⁴ ; Afsharpad M⁵ ; Shankaie K⁶ ; Samadaian N⁷

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
3. Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Cancer Control Research Center, Cancer Control Fundation, Iran University of Medical Sciences, Tehran, Iran
6. Department of Biology, Science and research branch, Islamic Azad University, Tehran, Iran
7. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Urology Journal Published:2019

Abstract

Purpose: This study aims to investigate the expression level of mir-let7b-3p and mir-548, which are involved in PTEN expression in tissue samples of prostate cancer patients versus benign prostate hyperplasia (BPH) and normal adjacent tissue. Materials and Methods: Prostate cancer tissues were obtained from patients after receiving informed consent. Total RNA extraction and cDNA synthesis were performed for determining gene expression. Results: Ten patients were determined to have high Gleason scores (> 7), 36 and seven samples had intermediate Gleason scores (7≥) and BPH, respectively, and 40 samples were derived from normal adjacent tissue. Downregulation of mir-let7b and upregulation of mir-548 expression significantly correlated with high-risk Gleason scores. Conclusion: The present study showed that miR-let7b and/or mir-548 can be considered as potential targets in prostate cancer therapy. © 2018 Urology and Nephrology Research Centre.

Related Docs

View other Related Docs

1. Inhibition of Phlpp1/2 Phosphatases Rescues Pancreatic Β-Cells in Diabetes, Cell Reports (2021)

2. Expression Profile of Mirnas in Urine Samples of Bladder Cancer Patients, Biomarkers in Medicine (2018)

3. Effects of Lactobacillus Acidophilus and Bifidobacterium Bifidum Probiotics on the Expression of Micrornas 135B, 26B, 18A and 155, and Their Involving Genes in Mice Colon Cancer, Probiotics and Antimicrobial Proteins (2019)

4. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)

5. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)

6. The Microrna Let-7 and Its Exosomal Form: Epigenetic Regulators of Gynecological Cancers, Cell Biology and Toxicology (2024)

7. Recent Advances in Lateral Flow Assays for Microrna Detection, Clinica Chimica Acta (2025)

8. Mir-199A-3P Modulates Mtor and Pak4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model, Molecular Therapy Nucleic Acids (2018)

Experts (# of related papers)

View all Related Experts

Hamid Reza Mirzaei (1)

Mohammad Hossein Modarressi (1)

Style	Citing Format
MLA	Saffari M, et al.. "The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer." Urology Journal, vol. 16, no. 3, 2019, pp. 267-273.
APA	Saffari M, Ghaderian SMH, Omrani MD, Afsharpad M, Shankaie K, Samadaian N (2019). The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer. Urology Journal, 16(3), 267-273.
Chicago	Saffari M, Ghaderian SMH, Omrani MD, Afsharpad M, Shankaie K, Samadaian N. "The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer." Urology Journal 16, no. 3 (2019): 267-273.
Harvard	Saffari M et al. (2019) 'The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer', Urology Journal, 16(3), pp. 267-273.
Vancouver	Saffari M, Ghaderian SMH, Omrani MD, Afsharpad M, Shankaie K, Samadaian N. The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer. Urology Journal. 2019;16(3):267-273.
BibTex	@article{ author = {Saffari M and Ghaderian SMH and Omrani MD and Afsharpad M and Shankaie K and Samadaian N}, title = {The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer}, journal = {Urology Journal}, volume = {16}, number = {3}, pages = {267-273}, year = {2019} }
RIS	TY - JOUR AU - Saffari M AU - Ghaderian SMH AU - Omrani MD AU - Afsharpad M AU - Shankaie K AU - Samadaian N TI - The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer JO - Urology Journal VL - 16 IS - 3 SP - 267 EP - 273 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract