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Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review Publisher



Sadeghi MS1 ; Lotfi M2 ; Soltani N3 ; Farmani E4 ; Fernandez JHO5 ; Akhlaghitehrani S6 ; Mohammed SH7 ; Yasamineh S8 ; Kalajahi HG9 ; Gholizadeh O8
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Science, Tehran, Iran
  3. 3. School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Universidad Peruana Los Andes, Huancayo, Peru
  6. 6. Faculty of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy
  7. 7. Collage of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq
  8. 8. Free Researcher, Viro & Biotech, Tehran, Iran
  9. 9. Department of Biotechnology, Institute of Science, Uskudar University, Istanbul, Turkey

Source: Cancer Cell International Published:2023


Abstract

Carcinoma of the lung is among the most common types of cancer globally. Concerning its histology, it is categorized as a non-small cell carcinoma (NSCLC) and a small cell cancer (SCLC) subtype. MicroRNAs (miRNAs) are a member of non-coding RNA whose nucleotides range from 19 to 25. They are known to be critical regulators of cancer via epigenetic control of oncogenes expression and by regulating tumor suppressor genes. miRNAs have an essential function in a tumorous microenvironment via modulating cancer cell growth, metastasis, angiogenesis, metabolism, and apoptosis. Moreover, a wide range of information produced via several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, and predictive marker functions in different types of lung malignancy. miRNA mimics or anti-miRNAs can be transferred into a lung cancer cell, with possible curative implications. As a result, miRNAs hold promise as targets for lung cancer treatment and detection. In this study, we investigate the different functions of various miRNAs in different types of lung malignancy, which have been achieved in recent years that show the lung cancer-associated regulation of miRNAs expression, concerning their function in lung cancer beginning, development, and resistance to chemotherapy, also the probability to utilize miRNAs as predictive biomarkers for therapy reaction. Graphical abstract: [Figure not available: see fulltext.] © 2023, The Author(s).
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