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Bioaerosol Exposure and Circulating Biomarkers in a Panel of Elderly Subjects and Healthy Young Adults Publisher Pubmed



Faridi S1, 2 ; Naddafi K1, 2 ; Kashani H3 ; Nabizadeh R1, 2 ; Alimohammadi M2 ; Momeniha F4 ; Faridi S1, 2 ; Niazi S2 ; Zare A6 ; Gholampour A7 ; Hoseini M8 ; Pourpak Z6 ; Hassanvand MS1, 2 ; Yunesian M1, 2
Authors
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Authors Affiliations
  1. 1. Center for Air Pollution Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Immunology, Department of Microbiology, Veterinary Faculty, Urmia University, Urmia, Iran
  6. 6. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Environmental Health Engineering, School of Public Health, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Environmental Health Engineering, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Science of the Total Environment Published:2017


Abstract

Numerous studies have found that risk of cardiovascular diseases is associated with increased blood levels of circulating markers of systemic inflammation. We investigated associations of acute exposure to bioaerosols (bacteria and fungi) with blood markers of inflammation and coagulation using panels of elderly subjects and healthy young adults. We conducted a panel study of 44 nonsmoker elderly subjects in a retirement communities and a panel study of 40 healthy young adults living in a school dormitory within Tehran city, Iran. Blood sample biomarkers were measured weekly over 6 weeks and including high sensitive C-reactive protein (hsCRP), tumor necrosis factor-soluble receptor-II (sTNF-RII), von Willebrand factor (vWF), white blood cells (WBC) count and interleukin-6 (IL-6). We found significant positive associations for IL-6 and WBC with exposure to Aspergillus spp. (As), Cladosporium spp. (Cl), Penicillium spp. (Pe), total fungi (TF) and Micrococcus spp. (MI); vWF with Cl and MI; sTNF-RII with Staphylococcus spp. (ST) in healthy young adults from the current-day and multiday averages. For elderly subjects, we observed significant positive associations for hsCRP, sTNF-RII and WBC with exposure to MI, but not with ST and total bacteria (TB). Our results showed the strongest significant positive associations for IL-6 with MI, ST and TB in elderly people. In addition, IL-6 was also positively associated with As, Cl and Pe in elderly. Also, the results showed that increase of vWF was significantly associated with bacterial and fungal aerosols, except Bacillus spp. (BA) at some lags in elderly subjects. Pooled results support the pivotal role of bioaerosols in increasing the level of some of inflammatory biomarkers, especially IL-6 and WBC in healthy young adults but possibly also in elderly people. © 2017 Elsevier B.V.
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