The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction

The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction Publisher Pubmed

Deravi N^{1, 2} ; Poudineh M^{3, 4} ; Pirzadeh M^{5, 6} ; Yavarpourbali H^{5, 6} ; Mehrabi H^{7, 8} ; Erabi G^{9, 10} ; Saghazadeh A^{2, 11} ; Rezaei N^{11, 12, 13}

Show Affiliations

1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
3. School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Zanjan, Iran
5. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
6. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Babol, Iran
7. Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran
8. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Arak, Iran
9. Student Research Committee, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
10. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Urmia, Iran
11. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
12. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
13. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: International Immunopharmacology Published:2022

Abstract

Endothelial cells (ECs) play a critical role in health and disease due to their widespread distribution and unique location. Although ECs are not regarded as classical immune cells, they actively participate in innate immune and inflammatory responses. EC function is affected by exogenous activators (i.e., infectious agents) and endogenous triggers (i.e., damage-associated molecular pattern molecules (DAMPs) released by stressed or injured cells). Toll-like receptors (TLRs) can recognize both infectious agents and DAMPs and play a key role in activating innate mechanisms in ECs. Endothelial dysfunction (EDF) may lead to tissue damage in various inflammatory and autoimmune diseases through TLRs. This review summarizes the current knowledge about the role of TLRs in a variety of EDF-related conditions, including autoimmunity and graft rejection, cancer, cardiovascular diseases, diabetes and related complications, ischemia and related injuries, and sepsis. © 2022 Elsevier B.V.

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Style	Citing Format
MLA	Deravi N, et al.. "The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction." International Immunopharmacology, vol. 108, no. , 2022, pp. -.
APA	Deravi N, Poudineh M, Pirzadeh M, Yavarpourbali H, Mehrabi H, Erabi G, Saghazadeh A, Rezaei N (2022). The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction. International Immunopharmacology, 108(), -.
Chicago	Deravi N, Poudineh M, Pirzadeh M, Yavarpourbali H, Mehrabi H, Erabi G, Saghazadeh A, Rezaei N. "The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction." International Immunopharmacology 108, no. (2022): -.
Harvard	Deravi N et al. (2022) 'The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction', International Immunopharmacology, 108(), pp. -.
Vancouver	Deravi N, Poudineh M, Pirzadeh M, Yavarpourbali H, Mehrabi H, Erabi G, et al.. The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction. International Immunopharmacology. 2022;108():-.
BibTex	@article{ author = {Deravi N and Poudineh M and Pirzadeh M and Yavarpourbali H and Mehrabi H and Erabi G and Saghazadeh A and Rezaei N}, title = {The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction}, journal = {International Immunopharmacology}, volume = {108}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Deravi N AU - Poudineh M AU - Pirzadeh M AU - Yavarpourbali H AU - Mehrabi H AU - Erabi G AU - Saghazadeh A AU - Rezaei N TI - The Yin and Yang of Toll-Like Receptors in Endothelial Dysfunction JO - International Immunopharmacology VL - 108 IS - SP - EP - PY - 2022 ER -

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