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The First Identification of Nanobacteria-Like Structures in Vascular Plaques of Atherosclerosis Patients in Iran Publisher



Majidpour A1 ; Rasouli S1 ; Sardarabadi H2 ; Noaparast M3 ; Khedmatgozar M1 ; Fathizadeh S1 ; Ghooshchian M1 ; Boustanshenas M1 ; Sadat SAM4
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Authors Affiliations
  1. 1. Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomedical Engineering and Medical Physics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Vascular and Endovascular Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Vascular and Endovascular Department, Yasuj University of Medical Sciences, Yasuj, Iran

Source: Archives of Clinical Infectious Diseases Published:2019


Abstract

Background: Nanobacteria-like structures (NLSs) or calcifying nanoscale particles (CNPs) are novel ambiguous entities. As their names imply, they are tiny creatures (100 to 500 nanometers). Compared to ordinary bacteria, they can exhibit some unbelievable properties such as resistance to conventional antibacterial procedures. Form a scale point of view, these microorganisms are much smaller than ordinary bacteria and are preserved from the outer environment by their rigid apatite shell. The above-mentioned protective properties of nanobacteria are responsible for a dangerous in vivo calcification procedure causing pathological infectious diseases. Objectives: The main goal of this study was to identify and isolate the nanobacteria from patients with atherosclerosis. Methods: Human vascular tissues were assessed for the presence of NLSs in atherosclerotic plaques at Sina Hospital, Tehran, Iran. All 40 samples obtained from patients as the wastes of surgery showed crystallization in vitro after about 10 days. Crystallization was seen also in filtered media. The precipitates of media were investigated by scanning electron microscopy (SEM). Results: NLSs were seen in all samples by SEM. After confirming the NLSs presence, they were characterized by TEM, XRD, and SEM/EDAX. Conclusions: The NLSs are observed in patients with atherosclerosis. © 2019, Archives of Clinical Infectious Diseases.
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