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Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution Publisher



Akbari Z1 ; Amanlou M2 ; Karimisabet J3 ; Golestani A4 ; Niassar MS1
Authors
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Authors Affiliations
  1. 1. Transport Phenomenon and NanoTechnology Laboratory TPNT, School of Chemical Engineering, College of Engineering, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Jaber Ebne Hayyan National Research Laboratory, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Nano Research Published:2015


Abstract

The purpose of this study was to prepare ibuprofen loaded solid lipid nanoparticles (IBUSLNs) that is, effective in oral drug delivery. IBU-SLNs were synthesized by co-precipitation of rapid expansion of supercritical solution (CO-RESS). The produced SLNs consisted of stearic acid as lipid matrix. The unprocessed stearic acid, ibuprofen and IBU-SLNs were characterized by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), fourier transform infrared spectrophotometry (FTIR) and high performance liquid chromatography (HPLC). XRD patterns along with DSC showed that ibuprofen was present in both amorphous and crystalline form within lipid matrix. FTIR showed that molecular interactions that could alter the chemical structure of the IBU did not occur. The RESS process could produce ultrafine spherical particles of SLNs with high drug loading capacity. The IBU dissolution profile showed that the formulated SLNs have effectively increased the IBU solubility. © (2015) Trans Tech Publications, Switzerland.
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