Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation

Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation Publisher Pubmed

Izadifard M¹ ; Ahmadvand M² ; Pashaiefar H¹ ; Alimoghadam K² ; Kasaeian A¹ ; Barkhordar M² ; Seghatoleslami G³ ; Vaezi M¹ ; Ghavamzadeh A^{1, 4} ; Yaghmaie M¹

Show Affiliations

1. Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology, and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
3. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Clinical Transplantation Published:2024

Abstract

Background: There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft-versus-host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognostic, or predictive biomarkers of aGVHD. Methods: In a prospective cohort, we studied the incidence of cutaneous aGVHD in AML patients undergoing allo-HSCT at Shariati Hospital in Tehran, Iran during 2020–2023. Patients with cutaneous aGVHD were labeled as the case group, while patients without cutaneous aGVHD were selected as the control group. Accordingly, the expression levels of six significant miRNAs (miR-638, miR-6511b-5p, miR-3613-5p, miR-455-3p, miR-5787, miR-548a-3p) were evaluated by quantitative reverse transcription–polymerase chain reaction (RTqPCR) in three different time-points: before transplantation, on day 14 and day 21 after transplantation. Results: The levels of plasma miR-455-3p, miR-5787, miR-638, and miR-3613-5p were significantly downregulated, while miR-548a-3p, and miR-6511b-5p were significantly upregulated in individuals with cutaneous aGVHD in comparison to patients without GVHD. Additionally, the possibility for great diagnostic accuracy for cutaneous aGVHD was revealed by ROC curve analysis of differentially expressed miRNAs (DEMs). Conclusion: The study findings encourage us to hypothesize that the aforementioned miRNAs may contribute to the predominance of aGVHD, particularly low-grade cutaneous aGVHD. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2. Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation, Gene Reports (2024)

3. Micrornas As Potential Diagnostic, Prognostic, and Predictive Biomarkers for Acute Graft-Versus-Host Disease, Biology of Blood and Marrow Transplantation (2019)

4. The Hsa-Mir-3613–5P, a Potential Oncogene Correlated With Diagnostic and Prognostic Merits in Kidney Renal Clear Cell Carcinoma, Pathology Research and Practice (2023)

5. Plasma-Circulating Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Noninvasive Biomarkers of Immune Reconstitution Post-Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients, Transplant Immunology (2025)

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Mohammad Ahmadvand (4)

Marjan Yaghmaie (4)

Style	Citing Format
MLA	Izadifard M, et al.. "Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation." Clinical Transplantation, vol. 38, no. 6, 2024, pp. -.
APA	Izadifard M, Ahmadvand M, Pashaiefar H, Alimoghadam K, Kasaeian A, Barkhordar M, Seghatoleslami G, Vaezi M, Ghavamzadeh A, Yaghmaie M (2024). Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation. Clinical Transplantation, 38(6), -.
Chicago	Izadifard M, Ahmadvand M, Pashaiefar H, Alimoghadam K, Kasaeian A, Barkhordar M, Seghatoleslami G, Vaezi M, Ghavamzadeh A, Yaghmaie M. "Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation." Clinical Transplantation 38, no. 6 (2024): -.
Harvard	Izadifard M et al. (2024) 'Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation', Clinical Transplantation, 38(6), pp. -.
Vancouver	Izadifard M, Ahmadvand M, Pashaiefar H, Alimoghadam K, Kasaeian A, Barkhordar M, et al.. Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation. Clinical Transplantation. 2024;38(6):-.
BibTex	@article{ author = {Izadifard M and Ahmadvand M and Pashaiefar H and Alimoghadam K and Kasaeian A and Barkhordar M and Seghatoleslami G and Vaezi M and Ghavamzadeh A and Yaghmaie M}, title = {Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation}, journal = {Clinical Transplantation}, volume = {38}, number = {6}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Izadifard M AU - Ahmadvand M AU - Pashaiefar H AU - Alimoghadam K AU - Kasaeian A AU - Barkhordar M AU - Seghatoleslami G AU - Vaezi M AU - Ghavamzadeh A AU - Yaghmaie M TI - Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma Mir-638, Mir-6511B-5P, Mir-3613-5P, Mir-455-3P, Mir-5787, and Mir-548A-3P As Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation JO - Clinical Transplantation VL - 38 IS - 6 SP - EP - PY - 2024 ER -

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